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Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a Patient with Turner Syndrome Mosaic
We describe a patient who underwent thoracic radiation therapy for biopsy-proven pulmonary spindle cell sarcoma in the left lower lobe, 15 months after birth. At the age of 37 she developed shoulder pain, fatigue, and progressive exertion dyspnoea. Chest X-ray revealed a pulmonary mass in the left l...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395496/ https://www.ncbi.nlm.nih.gov/pubmed/18521351 http://dx.doi.org/10.1080/1357714021000066395 |
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author | Brauer, Volker F. H. Reichenberger, Frank Müller, Anke Steinert, Matthias Froster, Ursula G. Wirtz, Hubert R. W. Schauer, Joachim |
author_facet | Brauer, Volker F. H. Reichenberger, Frank Müller, Anke Steinert, Matthias Froster, Ursula G. Wirtz, Hubert R. W. Schauer, Joachim |
author_sort | Brauer, Volker F. H. |
collection | PubMed |
description | We describe a patient who underwent thoracic radiation therapy for biopsy-proven pulmonary spindle cell sarcoma in the left lower lobe, 15 months after birth. At the age of 37 she developed shoulder pain, fatigue, and progressive exertion dyspnoea. Chest X-ray revealed a pulmonary mass in the left lower lobe due to a cytology-proven malignant tumour.The patient underwent left pneumonectomy. Histology revealed a myosarcoma of the lung, similar to the previous sarcoma. Furthermore, the patient was diagnosed to have Turner syndrome mosaic and chromosomal analysis revealed a translocation t(1;13) in 3/50 metaphases. However a germline mutation of the p53 tumour suppressor gene was excluded. After 2 years of follow-up the patient is stable and there are no signs of recurrence of the tumour.We conclude a re-occurrence of this very rare malignant disorder of the lung after a 36-year interval in a patient with Turner syndrome mosaic. Following initial curative radiation therapy, with a remission over 36 years, lung resection was now successfully performed. |
format | Text |
id | pubmed-2395496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23954962008-06-02 Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a Patient with Turner Syndrome Mosaic Brauer, Volker F. H. Reichenberger, Frank Müller, Anke Steinert, Matthias Froster, Ursula G. Wirtz, Hubert R. W. Schauer, Joachim Sarcoma Research Article We describe a patient who underwent thoracic radiation therapy for biopsy-proven pulmonary spindle cell sarcoma in the left lower lobe, 15 months after birth. At the age of 37 she developed shoulder pain, fatigue, and progressive exertion dyspnoea. Chest X-ray revealed a pulmonary mass in the left lower lobe due to a cytology-proven malignant tumour.The patient underwent left pneumonectomy. Histology revealed a myosarcoma of the lung, similar to the previous sarcoma. Furthermore, the patient was diagnosed to have Turner syndrome mosaic and chromosomal analysis revealed a translocation t(1;13) in 3/50 metaphases. However a germline mutation of the p53 tumour suppressor gene was excluded. After 2 years of follow-up the patient is stable and there are no signs of recurrence of the tumour.We conclude a re-occurrence of this very rare malignant disorder of the lung after a 36-year interval in a patient with Turner syndrome mosaic. Following initial curative radiation therapy, with a remission over 36 years, lung resection was now successfully performed. Hindawi Publishing Corporation 2002-12 /pmc/articles/PMC2395496/ /pubmed/18521351 http://dx.doi.org/10.1080/1357714021000066395 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Brauer, Volker F. H. Reichenberger, Frank Müller, Anke Steinert, Matthias Froster, Ursula G. Wirtz, Hubert R. W. Schauer, Joachim Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a Patient with Turner Syndrome Mosaic |
title | Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a
Patient with Turner Syndrome Mosaic |
title_full | Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a
Patient with Turner Syndrome Mosaic |
title_fullStr | Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a
Patient with Turner Syndrome Mosaic |
title_full_unstemmed | Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a
Patient with Turner Syndrome Mosaic |
title_short | Successful Resection of a Re-Occurred Pulmonary Myosarcoma in a
Patient with Turner Syndrome Mosaic |
title_sort | successful resection of a re-occurred pulmonary myosarcoma in a
patient with turner syndrome mosaic |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395496/ https://www.ncbi.nlm.nih.gov/pubmed/18521351 http://dx.doi.org/10.1080/1357714021000066395 |
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