A Sarcoma at the Site of Previous Extravasation of Adriamycin

We report the case of a 66-year-old man presenting with a high-grade pleomorphic sarcoma at the left elbow 16 years after the extravasation of adriamycin given for a malignant ifbrous histiocytoma of the tibia.We suggest that this sarcoma originated in a multistep way over many years, out of the chr...

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Detalles Bibliográficos
Autores principales: Ceulemans, Joris, De Wever, Ivo, Sciot, Raf, Debiec-Rychter, Maria, van Oosterom, Allan T.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395497/
https://www.ncbi.nlm.nih.gov/pubmed/18521350
http://dx.doi.org/10.1080/1357714021000066386
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author Ceulemans, Joris
De Wever, Ivo
Sciot, Raf
Debiec-Rychter, Maria
van Oosterom, Allan T.
author_facet Ceulemans, Joris
De Wever, Ivo
Sciot, Raf
Debiec-Rychter, Maria
van Oosterom, Allan T.
author_sort Ceulemans, Joris
collection PubMed
description We report the case of a 66-year-old man presenting with a high-grade pleomorphic sarcoma at the left elbow 16 years after the extravasation of adriamycin given for a malignant ifbrous histiocytoma of the tibia.We suggest that this sarcoma originated in a multistep way over many years, out of the chronic inflammatory tissue that developed due to a non-specific cellular damage at the nuclear level, interfering with normal cell replication necessary for normal healing tissue healing. As a result, the non-healed chronic inflammatory tissue transformed over several years into a preneoplastic mesenchymal tumour and later into a high-grade pleomorphic sarcoma.
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spelling pubmed-23954972008-06-02 A Sarcoma at the Site of Previous Extravasation of Adriamycin Ceulemans, Joris De Wever, Ivo Sciot, Raf Debiec-Rychter, Maria van Oosterom, Allan T. Sarcoma Research Article We report the case of a 66-year-old man presenting with a high-grade pleomorphic sarcoma at the left elbow 16 years after the extravasation of adriamycin given for a malignant ifbrous histiocytoma of the tibia.We suggest that this sarcoma originated in a multistep way over many years, out of the chronic inflammatory tissue that developed due to a non-specific cellular damage at the nuclear level, interfering with normal cell replication necessary for normal healing tissue healing. As a result, the non-healed chronic inflammatory tissue transformed over several years into a preneoplastic mesenchymal tumour and later into a high-grade pleomorphic sarcoma. Hindawi Publishing Corporation 2002-12 /pmc/articles/PMC2395497/ /pubmed/18521350 http://dx.doi.org/10.1080/1357714021000066386 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ceulemans, Joris
De Wever, Ivo
Sciot, Raf
Debiec-Rychter, Maria
van Oosterom, Allan T.
A Sarcoma at the Site of Previous Extravasation of Adriamycin
title A Sarcoma at the Site of Previous Extravasation of Adriamycin
title_full A Sarcoma at the Site of Previous Extravasation of Adriamycin
title_fullStr A Sarcoma at the Site of Previous Extravasation of Adriamycin
title_full_unstemmed A Sarcoma at the Site of Previous Extravasation of Adriamycin
title_short A Sarcoma at the Site of Previous Extravasation of Adriamycin
title_sort sarcoma at the site of previous extravasation of adriamycin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395497/
https://www.ncbi.nlm.nih.gov/pubmed/18521350
http://dx.doi.org/10.1080/1357714021000066386
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