Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy

Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported, with five cases of osteosarcoma described. Patie...

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Detalles Bibliográficos
Autores principales: Lee, Robert S., Higgs, Deborah, Haddo, Omar, Pringle, Jean, Briggs, Timothy W. R.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395602/
https://www.ncbi.nlm.nih.gov/pubmed/18521394
http://dx.doi.org/10.1080/13577140410001679266
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author Lee, Robert S.
Higgs, Deborah
Haddo, Omar
Pringle, Jean
Briggs, Timothy W. R.
author_facet Lee, Robert S.
Higgs, Deborah
Haddo, Omar
Pringle, Jean
Briggs, Timothy W. R.
author_sort Lee, Robert S.
collection PubMed
description Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported, with five cases of osteosarcoma described. Patient: A sixth case of a 12-year-old girl with DBA who developed an osteosarcoma of the distal femur is presented. Results: She was treated with methotrexate followed by tumour excision and distal femoral replacement. The patient is currently alive with multiple pulmonary metastases. Discussion: We discuss the association between the administration of growth hormone and future development of malignancy in patients with DBA.
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spelling pubmed-23956022008-06-02 Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy Lee, Robert S. Higgs, Deborah Haddo, Omar Pringle, Jean Briggs, Timothy W. R. Sarcoma Research Article Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported, with five cases of osteosarcoma described. Patient: A sixth case of a 12-year-old girl with DBA who developed an osteosarcoma of the distal femur is presented. Results: She was treated with methotrexate followed by tumour excision and distal femoral replacement. The patient is currently alive with multiple pulmonary metastases. Discussion: We discuss the association between the administration of growth hormone and future development of malignancy in patients with DBA. Hindawi Publishing Corporation 2004-03 /pmc/articles/PMC2395602/ /pubmed/18521394 http://dx.doi.org/10.1080/13577140410001679266 Text en Copyright © 2004 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lee, Robert S.
Higgs, Deborah
Haddo, Omar
Pringle, Jean
Briggs, Timothy W. R.
Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy
title Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy
title_full Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy
title_fullStr Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy
title_full_unstemmed Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy
title_short Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy
title_sort osteosarcoma associated with diamond-blackfan anaemia: a case of a child receiving growth hormone therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395602/
https://www.ncbi.nlm.nih.gov/pubmed/18521394
http://dx.doi.org/10.1080/13577140410001679266
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AT pringlejean osteosarcomaassociatedwithdiamondblackfananaemiaacaseofachildreceivinggrowthhormonetherapy
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