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A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS)
Purpose: The aim of this study was to determine the efficacy and safety of docetaxel plus epirubicin combination as first-line chemotherapy in patients with locally advanced and/or metastatic adult STS. Patients and Methods: Eighteen patients were treated with epirubicin 30 mg/m(2) on days 1 to 3 an...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395619/ https://www.ncbi.nlm.nih.gov/pubmed/18521407 http://dx.doi.org/10.1080/13577140400016705 |
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author | Kalofonos, Haralabos P. Kourousis, Charalabos Karamouzis, Michalis V. Iconomou, Gregoris Tsiata, Ekaterini Tzorzidis, Fotis Megas, Panagiotis Lambiris, Elias Georgoulias, Vasilios |
author_facet | Kalofonos, Haralabos P. Kourousis, Charalabos Karamouzis, Michalis V. Iconomou, Gregoris Tsiata, Ekaterini Tzorzidis, Fotis Megas, Panagiotis Lambiris, Elias Georgoulias, Vasilios |
author_sort | Kalofonos, Haralabos P. |
collection | PubMed |
description | Purpose: The aim of this study was to determine the efficacy and safety of docetaxel plus epirubicin combination as first-line chemotherapy in patients with locally advanced and/or metastatic adult STS. Patients and Methods: Eighteen patients were treated with epirubicin 30 mg/m(2) on days 1 to 3 and docetaxel 100 mg/m(2) on day 1 every 3 weeks. Results: Fifteen out of 18 patients (83.4%) were assessable for response. No complete response was recorded. Three (20%) patients achieved PR, 3 had SD and 9 PD. The overall median survival was 14 months (range, 3–48 months) and the median time to disease progression was 4 months (range, 2–45 months). Grade ≥ 3 neutropenia occurred in 88% and neutropenic fever in 27.8% of patients. Other toxicities were mild. No treatment related deaths occurred. Discussion: Docetaxel plus epirubicin combination achieved low response rate with severe myelotoxicity in patients with advanced STS. |
format | Text |
id | pubmed-2395619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23956192008-06-02 A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS) Kalofonos, Haralabos P. Kourousis, Charalabos Karamouzis, Michalis V. Iconomou, Gregoris Tsiata, Ekaterini Tzorzidis, Fotis Megas, Panagiotis Lambiris, Elias Georgoulias, Vasilios Sarcoma Research Article Purpose: The aim of this study was to determine the efficacy and safety of docetaxel plus epirubicin combination as first-line chemotherapy in patients with locally advanced and/or metastatic adult STS. Patients and Methods: Eighteen patients were treated with epirubicin 30 mg/m(2) on days 1 to 3 and docetaxel 100 mg/m(2) on day 1 every 3 weeks. Results: Fifteen out of 18 patients (83.4%) were assessable for response. No complete response was recorded. Three (20%) patients achieved PR, 3 had SD and 9 PD. The overall median survival was 14 months (range, 3–48 months) and the median time to disease progression was 4 months (range, 2–45 months). Grade ≥ 3 neutropenia occurred in 88% and neutropenic fever in 27.8% of patients. Other toxicities were mild. No treatment related deaths occurred. Discussion: Docetaxel plus epirubicin combination achieved low response rate with severe myelotoxicity in patients with advanced STS. Hindawi Publishing Corporation 2004-12 /pmc/articles/PMC2395619/ /pubmed/18521407 http://dx.doi.org/10.1080/13577140400016705 Text en Copyright © 2004 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kalofonos, Haralabos P. Kourousis, Charalabos Karamouzis, Michalis V. Iconomou, Gregoris Tsiata, Ekaterini Tzorzidis, Fotis Megas, Panagiotis Lambiris, Elias Georgoulias, Vasilios A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS) |
title | A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS) |
title_full | A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS) |
title_fullStr | A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS) |
title_full_unstemmed | A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS) |
title_short | A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS) |
title_sort | phase ii study of docetaxel and epirubicin in advanced adult soft tissue sarcomas (sts) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395619/ https://www.ncbi.nlm.nih.gov/pubmed/18521407 http://dx.doi.org/10.1080/13577140400016705 |
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