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Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition
The Rag1 and Rag2 proteins initiate V(D)J recombination by introducing site-specific DNA double-strand breaks. Cleavage occurs by nicking one DNA strand, followed by a one-step transesterification reaction that forms a DNA hairpin structure. A similar reaction allows Rag transposition, in which the...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396405/ https://www.ncbi.nlm.nih.gov/pubmed/18375979 http://dx.doi.org/10.1093/nar/gkn128 |