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End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
DNA polymerase μ is a member of the mammalian pol X family and reduces deletion during chromosome break repair by nonhomologous end joining (NHEJ). This biological role is linked to pol μ's ability to promote NHEJ of ends with noncomplementary 3′ overhangs, but questions remain regarding how it...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396419/ https://www.ncbi.nlm.nih.gov/pubmed/18397950 http://dx.doi.org/10.1093/nar/gkn164 |