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Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396474/ https://www.ncbi.nlm.nih.gov/pubmed/18604255 http://dx.doi.org/10.1093/ecam/nem015 |
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author | Pokharel, Yuba Raj Lim, Sung Chul Kim, Sang Chan Heo, Tae-Hwe Choi, Hoo Kyun Kang, Keon Wook |
author_facet | Pokharel, Yuba Raj Lim, Sung Chul Kim, Sang Chan Heo, Tae-Hwe Choi, Hoo Kyun Kang, Keon Wook |
author_sort | Pokharel, Yuba Raj |
collection | PubMed |
description | Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-κB activation, which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SYT on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SYT. |
format | Text |
id | pubmed-2396474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-23964742008-07-03 Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice Pokharel, Yuba Raj Lim, Sung Chul Kim, Sang Chan Heo, Tae-Hwe Choi, Hoo Kyun Kang, Keon Wook Evid Based Complement Alternat Med Original Articles – Basic Science Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-κB activation, which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SYT on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SYT. Oxford University Press 2008-06 2007-03-12 /pmc/articles/PMC2396474/ /pubmed/18604255 http://dx.doi.org/10.1093/ecam/nem015 Text en © 2007 The Author(s). http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles – Basic Science Pokharel, Yuba Raj Lim, Sung Chul Kim, Sang Chan Heo, Tae-Hwe Choi, Hoo Kyun Kang, Keon Wook Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice |
title | Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice |
title_full | Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice |
title_fullStr | Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice |
title_full_unstemmed | Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice |
title_short | Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice |
title_sort | sopungyangjae-tang inhibits development of dermatitis in nc/nga mice |
topic | Original Articles – Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396474/ https://www.ncbi.nlm.nih.gov/pubmed/18604255 http://dx.doi.org/10.1093/ecam/nem015 |
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