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Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice

Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga...

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Autores principales: Pokharel, Yuba Raj, Lim, Sung Chul, Kim, Sang Chan, Heo, Tae-Hwe, Choi, Hoo Kyun, Kang, Keon Wook
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396474/
https://www.ncbi.nlm.nih.gov/pubmed/18604255
http://dx.doi.org/10.1093/ecam/nem015
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author Pokharel, Yuba Raj
Lim, Sung Chul
Kim, Sang Chan
Heo, Tae-Hwe
Choi, Hoo Kyun
Kang, Keon Wook
author_facet Pokharel, Yuba Raj
Lim, Sung Chul
Kim, Sang Chan
Heo, Tae-Hwe
Choi, Hoo Kyun
Kang, Keon Wook
author_sort Pokharel, Yuba Raj
collection PubMed
description Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-κB activation, which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SYT on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SYT.
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spelling pubmed-23964742008-07-03 Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice Pokharel, Yuba Raj Lim, Sung Chul Kim, Sang Chan Heo, Tae-Hwe Choi, Hoo Kyun Kang, Keon Wook Evid Based Complement Alternat Med Original Articles – Basic Science Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-κB activation, which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SYT on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SYT. Oxford University Press 2008-06 2007-03-12 /pmc/articles/PMC2396474/ /pubmed/18604255 http://dx.doi.org/10.1093/ecam/nem015 Text en © 2007 The Author(s). http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles – Basic Science
Pokharel, Yuba Raj
Lim, Sung Chul
Kim, Sang Chan
Heo, Tae-Hwe
Choi, Hoo Kyun
Kang, Keon Wook
Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
title Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
title_full Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
title_fullStr Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
title_full_unstemmed Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
title_short Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
title_sort sopungyangjae-tang inhibits development of dermatitis in nc/nga mice
topic Original Articles – Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396474/
https://www.ncbi.nlm.nih.gov/pubmed/18604255
http://dx.doi.org/10.1093/ecam/nem015
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