Homeostatic Imbalance between Apoptosis and Cell Renewal in the Liver of Premature Aging Xpd(TTD) Mice

Unrepaired or misrepaired DNA damage has been implicated as a causal factor in cancer and aging. Xpd(TTD) mice, harboring defects in nucleotide excision repair and transcription due to a mutation in the Xpd gene (R722W), display severe symptoms of premature aging but have a reduced incidence of canc...

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Detalles Bibliográficos
Autores principales: Park, Jung Yoon, Cho, Mi-Ook, Leonard, Shanique, Calder, Brent, Mian, I. Saira, Kim, Woo Ho, Wijnhoven, Susan, van Steeg, Harry, Mitchell, James, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan, Cohen, Pinchas, Vijg, Jan, Suh, Yousin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396506/
https://www.ncbi.nlm.nih.gov/pubmed/18545656
http://dx.doi.org/10.1371/journal.pone.0002346

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