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Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis

The importance of the DNA damage response (DDR) pathway in development, genomic stability, and tumor suppression is well recognized. Although 53BP1 and MDC1 have been recently identified as critical upstream mediators in the cellular response to DNA double-strand breaks, their relative hierarchy in...

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Detalles Bibliográficos
Autores principales:	Minter-Dykhouse, Katherine, Ward, Irene, Huen, Michael S.Y., Chen, Junjie, Lou, Zhenkun
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396806/ https://www.ncbi.nlm.nih.gov/pubmed/18504301 http://dx.doi.org/10.1083/jcb.200801083

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