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Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin

Mutant huntingtin accumulates in the neuronal nuclei and processes, which suggests that its subcellular localization is critical for the pathology of Huntington's disease (HD). However, the contribution of cytoplasmic mutant huntingtin and its aggregates in neuronal processes (neuropil aggregat...

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Detalles Bibliográficos
Autores principales:	Wang, Chuan-En, Zhou, Hui, McGuire, John R., Cerullo, Vincenzo, Lee, Brendan, Li, Shi-Hua, Li, Xiao-Jiang
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396813/ https://www.ncbi.nlm.nih.gov/pubmed/18504298 http://dx.doi.org/10.1083/jcb.200710158

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