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Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1
We describe a novel strategy in which two inhibitors of HIV viral entry were incorporated into a single molecule. This bifunctional fusion inhibitor consists of an antibody blocking the binding of HIV to its co-receptor CCR5, and a covalently linked peptide which blocks envelope mediated virus-cell...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397382/ https://www.ncbi.nlm.nih.gov/pubmed/18452606 http://dx.doi.org/10.1186/1743-422X-5-56 |