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Incentive motivation in first-episode psychosis: A behavioural study

BACKGROUND: It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue. METHODS: We studied incentive motivation in 18 first-episode psychosis patie...

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Autores principales: Murray, Graham K, Clark, Luke, Corlett, Philip R, Blackwell, Andrew D, Cools, Roshan, Jones, Peter B, Robbins, Trevor W, Poustka, Luise
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397419/
https://www.ncbi.nlm.nih.gov/pubmed/18466609
http://dx.doi.org/10.1186/1471-244X-8-34
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author Murray, Graham K
Clark, Luke
Corlett, Philip R
Blackwell, Andrew D
Cools, Roshan
Jones, Peter B
Robbins, Trevor W
Poustka, Luise
author_facet Murray, Graham K
Clark, Luke
Corlett, Philip R
Blackwell, Andrew D
Cools, Roshan
Jones, Peter B
Robbins, Trevor W
Poustka, Luise
author_sort Murray, Graham K
collection PubMed
description BACKGROUND: It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue. METHODS: We studied incentive motivation in 18 first-episode psychosis patients from the Cambridge early psychosis service CAMEO and 19 control participants using the Cued Reinforcement Reaction Time Task, which measures motivationally driven behaviour. We also gathered information on participants' attentional, executive and spatial working memory function in order to determine whether any incentive motivation deficits were secondary to generalised cognitive impairment. RESULTS: We demonstrated the anticipated "reinforcement-related speeding" effect in controls (17 out of 19 control participants responded faster during an "odd-one-out" task in response to a cue that indicated a high likelihood of a large points reward). Only 4 out of 18 patients showed this effect and there was a significant interaction effect between reinforcement probability and diagnosis on reaction time (F(1,35 )= 14.2, p = 0.001). This deficit was present in spite of preserved executive and attentional function in patients, and persisted even in antipsychotic medication free patients. CONCLUSION: There are incentive motivation processing abnormalities in first-episode psychosis; these may be secondary to dopamine dysfunction and are not attributable to generalised cognitive impairment.
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spelling pubmed-23974192008-05-29 Incentive motivation in first-episode psychosis: A behavioural study Murray, Graham K Clark, Luke Corlett, Philip R Blackwell, Andrew D Cools, Roshan Jones, Peter B Robbins, Trevor W Poustka, Luise BMC Psychiatry Research Article BACKGROUND: It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue. METHODS: We studied incentive motivation in 18 first-episode psychosis patients from the Cambridge early psychosis service CAMEO and 19 control participants using the Cued Reinforcement Reaction Time Task, which measures motivationally driven behaviour. We also gathered information on participants' attentional, executive and spatial working memory function in order to determine whether any incentive motivation deficits were secondary to generalised cognitive impairment. RESULTS: We demonstrated the anticipated "reinforcement-related speeding" effect in controls (17 out of 19 control participants responded faster during an "odd-one-out" task in response to a cue that indicated a high likelihood of a large points reward). Only 4 out of 18 patients showed this effect and there was a significant interaction effect between reinforcement probability and diagnosis on reaction time (F(1,35 )= 14.2, p = 0.001). This deficit was present in spite of preserved executive and attentional function in patients, and persisted even in antipsychotic medication free patients. CONCLUSION: There are incentive motivation processing abnormalities in first-episode psychosis; these may be secondary to dopamine dysfunction and are not attributable to generalised cognitive impairment. BioMed Central 2008-05-08 /pmc/articles/PMC2397419/ /pubmed/18466609 http://dx.doi.org/10.1186/1471-244X-8-34 Text en Copyright © 2008 Murray et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Murray, Graham K
Clark, Luke
Corlett, Philip R
Blackwell, Andrew D
Cools, Roshan
Jones, Peter B
Robbins, Trevor W
Poustka, Luise
Incentive motivation in first-episode psychosis: A behavioural study
title Incentive motivation in first-episode psychosis: A behavioural study
title_full Incentive motivation in first-episode psychosis: A behavioural study
title_fullStr Incentive motivation in first-episode psychosis: A behavioural study
title_full_unstemmed Incentive motivation in first-episode psychosis: A behavioural study
title_short Incentive motivation in first-episode psychosis: A behavioural study
title_sort incentive motivation in first-episode psychosis: a behavioural study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397419/
https://www.ncbi.nlm.nih.gov/pubmed/18466609
http://dx.doi.org/10.1186/1471-244X-8-34
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