Cargando…
Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer
BACKGROUND: Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mechanisms inherent to tumor progression. In this work, we have investigated the cli...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397429/ https://www.ncbi.nlm.nih.gov/pubmed/18452596 http://dx.doi.org/10.1186/1471-2407-8-123 |
_version_ | 1782155624220459008 |
---|---|
author | Oh, Sung Yong Kwon, Hyuk-Chan Kim, Sung-Hyun Jang, Jin Seok Kim, Min Chan Kim, Kyeong Hee Han, Jin-Yeong Kim, Chung Ock Kim, Su-Jin Jeong, Jin-sook Kim, Hyo-Jin |
author_facet | Oh, Sung Yong Kwon, Hyuk-Chan Kim, Sung-Hyun Jang, Jin Seok Kim, Min Chan Kim, Kyeong Hee Han, Jin-Yeong Kim, Chung Ock Kim, Su-Jin Jeong, Jin-sook Kim, Hyo-Jin |
author_sort | Oh, Sung Yong |
collection | PubMed |
description | BACKGROUND: Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mechanisms inherent to tumor progression. In this work, we have investigated the clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF (sVEGF) level in gastric cancer. We immunohistochemically assessed the HIF-1α, p53, and VEGF expression patterns in 114 specimens of gastric cancer. Additionally, we determined the levels of preoperative serum VEGF (sVEGF). RESULTS: The positive rates of p53 and HIF-1α (diffuse, deep, intravascular pattern) were 38.6% and 15.8%, respectively. The VEGF overexpression rate was 57.9%. p53 and HIF-1α were correlated positively with the depth of invasion (P = 0.015, P = 0.001, respectively). Preoperative sVEGF and p53 levels were correlated significantly with lymph node involvement (P = 0.010, P = 0.040, respectively). VEGF overexpression was more frequently observed in the old age group (≥ 60 years old) and the intestinal type (P = 0.013, P = 0.014, respectively). However, correlations between preoperative sVEGF level and tissue HIF-1α, VEGF, and p53 were not observed. The median follow-up duration after operation was 24.5 months. HIF-1α was observed to be a poor prognostic factor of disease recurrence or progression (P = 0.002). CONCLUSION: p53, HIF-1α and preoperative sVEGF might be markers of depth of invasion or lymph node involvement. HIF-1α expression was a poor prognostic factor of disease recurrence or progression in patients with gastric cancers. |
format | Text |
id | pubmed-2397429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-23974292008-05-29 Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer Oh, Sung Yong Kwon, Hyuk-Chan Kim, Sung-Hyun Jang, Jin Seok Kim, Min Chan Kim, Kyeong Hee Han, Jin-Yeong Kim, Chung Ock Kim, Su-Jin Jeong, Jin-sook Kim, Hyo-Jin BMC Cancer Research Article BACKGROUND: Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mechanisms inherent to tumor progression. In this work, we have investigated the clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF (sVEGF) level in gastric cancer. We immunohistochemically assessed the HIF-1α, p53, and VEGF expression patterns in 114 specimens of gastric cancer. Additionally, we determined the levels of preoperative serum VEGF (sVEGF). RESULTS: The positive rates of p53 and HIF-1α (diffuse, deep, intravascular pattern) were 38.6% and 15.8%, respectively. The VEGF overexpression rate was 57.9%. p53 and HIF-1α were correlated positively with the depth of invasion (P = 0.015, P = 0.001, respectively). Preoperative sVEGF and p53 levels were correlated significantly with lymph node involvement (P = 0.010, P = 0.040, respectively). VEGF overexpression was more frequently observed in the old age group (≥ 60 years old) and the intestinal type (P = 0.013, P = 0.014, respectively). However, correlations between preoperative sVEGF level and tissue HIF-1α, VEGF, and p53 were not observed. The median follow-up duration after operation was 24.5 months. HIF-1α was observed to be a poor prognostic factor of disease recurrence or progression (P = 0.002). CONCLUSION: p53, HIF-1α and preoperative sVEGF might be markers of depth of invasion or lymph node involvement. HIF-1α expression was a poor prognostic factor of disease recurrence or progression in patients with gastric cancers. BioMed Central 2008-05-01 /pmc/articles/PMC2397429/ /pubmed/18452596 http://dx.doi.org/10.1186/1471-2407-8-123 Text en Copyright © 2008 Oh et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Oh, Sung Yong Kwon, Hyuk-Chan Kim, Sung-Hyun Jang, Jin Seok Kim, Min Chan Kim, Kyeong Hee Han, Jin-Yeong Kim, Chung Ock Kim, Su-Jin Jeong, Jin-sook Kim, Hyo-Jin Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer |
title | Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer |
title_full | Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer |
title_fullStr | Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer |
title_full_unstemmed | Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer |
title_short | Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer |
title_sort | clinicopathologic significance of hif-1α, p53, and vegf expression and preoperative serum vegf level in gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397429/ https://www.ncbi.nlm.nih.gov/pubmed/18452596 http://dx.doi.org/10.1186/1471-2407-8-123 |
work_keys_str_mv | AT ohsungyong clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT kwonhyukchan clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT kimsunghyun clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT jangjinseok clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT kimminchan clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT kimkyeonghee clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT hanjinyeong clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT kimchungock clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT kimsujin clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT jeongjinsook clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer AT kimhyojin clinicopathologicsignificanceofhif1ap53andvegfexpressionandpreoperativeserumvegflevelingastriccancer |