Indirect genomic effects on survival from gene expression data

In cancer, genes may have indirect effects on patient survival, mediated through interactions with other genes. Methods to study the indirect effects that contribute significantly to survival are not available. We propose a novel methodology to detect and quantify indirect effects from gene expressi...

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Detalles Bibliográficos
Autores principales: Ferkingstad, Egil, Frigessi, Arnoldo, Lyng, Heidi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397510/
https://www.ncbi.nlm.nih.gov/pubmed/18358079
http://dx.doi.org/10.1186/gb-2008-9-3-r58
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author Ferkingstad, Egil
Frigessi, Arnoldo
Lyng, Heidi
author_facet Ferkingstad, Egil
Frigessi, Arnoldo
Lyng, Heidi
author_sort Ferkingstad, Egil
collection PubMed
description In cancer, genes may have indirect effects on patient survival, mediated through interactions with other genes. Methods to study the indirect effects that contribute significantly to survival are not available. We propose a novel methodology to detect and quantify indirect effects from gene expression data. We discover indirect effects through several target genes of transcription factors in cancer microarray data, pointing to genetic interactions that play a significant role in tumor progression.
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spelling pubmed-23975102008-05-30 Indirect genomic effects on survival from gene expression data Ferkingstad, Egil Frigessi, Arnoldo Lyng, Heidi Genome Biol Method In cancer, genes may have indirect effects on patient survival, mediated through interactions with other genes. Methods to study the indirect effects that contribute significantly to survival are not available. We propose a novel methodology to detect and quantify indirect effects from gene expression data. We discover indirect effects through several target genes of transcription factors in cancer microarray data, pointing to genetic interactions that play a significant role in tumor progression. BioMed Central 2008-03-22 /pmc/articles/PMC2397510/ /pubmed/18358079 http://dx.doi.org/10.1186/gb-2008-9-3-r58 Text en Copyright © 2008 Ferkingstad et al.; licensee BioMed Central Ltd. https://creativecommons.org/licenses/by/2.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0 (https://creativecommons.org/licenses/by/2.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Ferkingstad, Egil
Frigessi, Arnoldo
Lyng, Heidi
Indirect genomic effects on survival from gene expression data
title Indirect genomic effects on survival from gene expression data
title_full Indirect genomic effects on survival from gene expression data
title_fullStr Indirect genomic effects on survival from gene expression data
title_full_unstemmed Indirect genomic effects on survival from gene expression data
title_short Indirect genomic effects on survival from gene expression data
title_sort indirect genomic effects on survival from gene expression data
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397510/
https://www.ncbi.nlm.nih.gov/pubmed/18358079
http://dx.doi.org/10.1186/gb-2008-9-3-r58
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AT lyngheidi indirectgenomiceffectsonsurvivalfromgeneexpressiondata

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