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Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site

BACKGROUND: The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function. RESULTS: The structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide...

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Autores principales: Ladner, Jane E, Obmolova, Galina, Teplyakov, Alexey, Howard, Andrew J, Khil, Pavel P, Camerini-Otero, R Daniel, Gilliland, Gary L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239858/
https://www.ncbi.nlm.nih.gov/pubmed/14519207
http://dx.doi.org/10.1186/1472-6807-3-7
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author Ladner, Jane E
Obmolova, Galina
Teplyakov, Alexey
Howard, Andrew J
Khil, Pavel P
Camerini-Otero, R Daniel
Gilliland, Gary L
author_facet Ladner, Jane E
Obmolova, Galina
Teplyakov, Alexey
Howard, Andrew J
Khil, Pavel P
Camerini-Otero, R Daniel
Gilliland, Gary L
author_sort Ladner, Jane E
collection PubMed
description BACKGROUND: The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function. RESULTS: The structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide chain binds two metal ions on the inside of the toroid. CONCLUSION: The toroidal structure is comparable to that of some proteins that are involved in DNA metabolism. The di-nuclear metal site could imply that the specific function of this protein is as a hydrolase-oxidase enzyme.
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spelling pubmed-2398582003-11-04 Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site Ladner, Jane E Obmolova, Galina Teplyakov, Alexey Howard, Andrew J Khil, Pavel P Camerini-Otero, R Daniel Gilliland, Gary L BMC Struct Biol Research Article BACKGROUND: The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function. RESULTS: The structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide chain binds two metal ions on the inside of the toroid. CONCLUSION: The toroidal structure is comparable to that of some proteins that are involved in DNA metabolism. The di-nuclear metal site could imply that the specific function of this protein is as a hydrolase-oxidase enzyme. BioMed Central 2003-09-30 /pmc/articles/PMC239858/ /pubmed/14519207 http://dx.doi.org/10.1186/1472-6807-3-7 Text en Copyright © 2003 Ladner et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Ladner, Jane E
Obmolova, Galina
Teplyakov, Alexey
Howard, Andrew J
Khil, Pavel P
Camerini-Otero, R Daniel
Gilliland, Gary L
Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
title Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
title_full Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
title_fullStr Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
title_full_unstemmed Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
title_short Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site
title_sort crystal structure of escherichia coli protein ybgi, a toroidal structure with a dinuclear metal site
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239858/
https://www.ncbi.nlm.nih.gov/pubmed/14519207
http://dx.doi.org/10.1186/1472-6807-3-7
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