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Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium
Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli in...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239898/ https://www.ncbi.nlm.nih.gov/pubmed/14577832 http://dx.doi.org/10.1186/1477-7827-1-71 |
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author | Choi, Kyung-Chul Auersperg, Nelly Leung, Peter CK |
author_facet | Choi, Kyung-Chul Auersperg, Nelly Leung, Peter CK |
author_sort | Choi, Kyung-Chul |
collection | PubMed |
description | Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells. Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer. In this article, an activation of the MAPK signaling cascade by several key reproductive hormones and growth factors in epithelial ovarian cancer is reviewed. |
format | Text |
id | pubmed-239898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-2398982003-11-04 Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium Choi, Kyung-Chul Auersperg, Nelly Leung, Peter CK Reprod Biol Endocrinol Review Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells. Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer. In this article, an activation of the MAPK signaling cascade by several key reproductive hormones and growth factors in epithelial ovarian cancer is reviewed. BioMed Central 2003-10-07 /pmc/articles/PMC239898/ /pubmed/14577832 http://dx.doi.org/10.1186/1477-7827-1-71 Text en Copyright © 2003 Choi et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Review Choi, Kyung-Chul Auersperg, Nelly Leung, Peter CK Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
title | Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
title_full | Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
title_fullStr | Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
title_full_unstemmed | Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
title_short | Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
title_sort | mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239898/ https://www.ncbi.nlm.nih.gov/pubmed/14577832 http://dx.doi.org/10.1186/1477-7827-1-71 |
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