Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

Presenilin (PS1 or PS2) is an essential component of the active γ-secretase complex that liberates the Aβ peptides from amyloid precursor protein (APP). PS1 is regarded as an atypical aspartyl protease harboring two essential aspartic acids in the context of the sequence D257LV and D385FI, respectiv...

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Detalles Bibliográficos
Autores principales: Carter, Donald B, Dunn, Edwige, Pauley, Adele M, McKinley, Denise D, Fleck, Timothy J, Ellerbrook, Brenda R, Stratman, Nancy C, Zhou, Xiangdong, Himes, Carol S, Nye, Jeffrey S, Tomasselli, Alfredo, Yan, Riqiang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2405781/
https://www.ncbi.nlm.nih.gov/pubmed/18474109
http://dx.doi.org/10.1186/1750-1326-3-6

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