Large-Scale Mutagenesis in p19(ARF)- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks

p53 and p19(ARF) are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either p53 or p19(ARF) deficiency, we identified 10,806 retroviral insertion sites, implicating over 300 loci in tumorigenesis. This dataset reveals 20 gene...

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Detalles Bibliográficos
Autores principales: Uren, Anthony G., Kool, Jaap, Matentzoglu, Konstantin, de Ridder, Jeroen, Mattison, Jenny, van Uitert, Miranda, Lagcher, Wendy, Sie, Daoud, Tanger, Ellen, Cox, Tony, Reinders, Marcel, Hubbard, Tim J., Rogers, Jane, Jonkers, Jos, Wessels, Lodewyk, Adams, David J., van Lohuizen, Maarten, Berns, Anton
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2405818/
https://www.ncbi.nlm.nih.gov/pubmed/18485879
http://dx.doi.org/10.1016/j.cell.2008.03.021

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