Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes

BACKGROUND: Chromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occasional chromosome missegregations during cell division. Two of the causes of CIN are weakened mitotic checkpoint signaling and persistent merotelic attachments that result in lagging chrom...

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Detalles Bibliográficos
Autores principales: Jelluma, Nannette, Brenkman, Arjan B., McLeod, Ian, Yates, John R., Cleveland, Don W., Medema, René H., Kops, Geert J. P. L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408436/
https://www.ncbi.nlm.nih.gov/pubmed/18545697
http://dx.doi.org/10.1371/journal.pone.0002415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408436/
https://www.ncbi.nlm.nih.gov/pubmed/18545697
http://dx.doi.org/10.1371/journal.pone.0002415

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