Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity

The premature human aging Werner syndrome (WS) is caused by mutation of the RecQ-family WRN helicase, which is unique in possessing also 3′–5′ exonuclease activity. WS patients show significant genomic instability with elevated cancer incidence. WRN is implicated in restraining illegitimate recombin...

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Detalles Bibliográficos
Autores principales: Saunders, Robert D C, Boubriak, Ivan, Clancy, David J, Cox, Lynne S
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408639/
https://www.ncbi.nlm.nih.gov/pubmed/18346216
http://dx.doi.org/10.1111/j.1474-9726.2008.00388.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408639/
https://www.ncbi.nlm.nih.gov/pubmed/18346216
http://dx.doi.org/10.1111/j.1474-9726.2008.00388.x

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