Cargando…
Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408640/ https://www.ncbi.nlm.nih.gov/pubmed/18284659 http://dx.doi.org/10.1111/j.1474-9726.2008.00380.x |
_version_ | 1782155691669061632 |
---|---|
author | Choi, Na-Hyun Kim, Joong-Gook Yang, Dong-Jin Kim, Young-Shin Yoo, Mi-Ae |
author_facet | Choi, Na-Hyun Kim, Joong-Gook Yang, Dong-Jin Kim, Young-Shin Yoo, Mi-Ae |
author_sort | Choi, Na-Hyun |
collection | PubMed |
description | Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the study of stem cell renewal and aging. Here we describe an age-related increase in the number and activity of intestinal stem cells (ISCs) and progenitor cells in Drosophila midgut. We determined that oxidative stress, induced by paraquat treatment or loss of catalase function, mimicked the changes associated with aging in the midgut. Furthermore, we discovered an age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations. Taken together, our findings suggest that PDGF/VEGF may play a central role in age-related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells. |
format | Text |
id | pubmed-2408640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-24086402008-06-09 Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor Choi, Na-Hyun Kim, Joong-Gook Yang, Dong-Jin Kim, Young-Shin Yoo, Mi-Ae Aging Cell Original Articles Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the study of stem cell renewal and aging. Here we describe an age-related increase in the number and activity of intestinal stem cells (ISCs) and progenitor cells in Drosophila midgut. We determined that oxidative stress, induced by paraquat treatment or loss of catalase function, mimicked the changes associated with aging in the midgut. Furthermore, we discovered an age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations. Taken together, our findings suggest that PDGF/VEGF may play a central role in age-related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells. Blackwell Publishing Ltd 2008-06 /pmc/articles/PMC2408640/ /pubmed/18284659 http://dx.doi.org/10.1111/j.1474-9726.2008.00380.x Text en © The Authors Journal compilation © Blackwell Publishing Ltd/The Anatomical Society of Great Britain and Ireland 2008 https://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2·5, which does not permit commercial exploitation. |
spellingShingle | Original Articles Choi, Na-Hyun Kim, Joong-Gook Yang, Dong-Jin Kim, Young-Shin Yoo, Mi-Ae Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor |
title | Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor |
title_full | Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor |
title_fullStr | Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor |
title_full_unstemmed | Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor |
title_short | Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor |
title_sort | age-related changes in drosophila midgut are associated with pvf2, a pdgf/vegf-like growth factor |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408640/ https://www.ncbi.nlm.nih.gov/pubmed/18284659 http://dx.doi.org/10.1111/j.1474-9726.2008.00380.x |
work_keys_str_mv | AT choinahyun agerelatedchangesindrosophilamidgutareassociatedwithpvf2apdgfvegflikegrowthfactor AT kimjoonggook agerelatedchangesindrosophilamidgutareassociatedwithpvf2apdgfvegflikegrowthfactor AT yangdongjin agerelatedchangesindrosophilamidgutareassociatedwithpvf2apdgfvegflikegrowthfactor AT kimyoungshin agerelatedchangesindrosophilamidgutareassociatedwithpvf2apdgfvegflikegrowthfactor AT yoomiae agerelatedchangesindrosophilamidgutareassociatedwithpvf2apdgfvegflikegrowthfactor |