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Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor

Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the...

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Autores principales: Choi, Na-Hyun, Kim, Joong-Gook, Yang, Dong-Jin, Kim, Young-Shin, Yoo, Mi-Ae
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408640/
https://www.ncbi.nlm.nih.gov/pubmed/18284659
http://dx.doi.org/10.1111/j.1474-9726.2008.00380.x
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author Choi, Na-Hyun
Kim, Joong-Gook
Yang, Dong-Jin
Kim, Young-Shin
Yoo, Mi-Ae
author_facet Choi, Na-Hyun
Kim, Joong-Gook
Yang, Dong-Jin
Kim, Young-Shin
Yoo, Mi-Ae
author_sort Choi, Na-Hyun
collection PubMed
description Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the study of stem cell renewal and aging. Here we describe an age-related increase in the number and activity of intestinal stem cells (ISCs) and progenitor cells in Drosophila midgut. We determined that oxidative stress, induced by paraquat treatment or loss of catalase function, mimicked the changes associated with aging in the midgut. Furthermore, we discovered an age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations. Taken together, our findings suggest that PDGF/VEGF may play a central role in age-related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells.
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spelling pubmed-24086402008-06-09 Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor Choi, Na-Hyun Kim, Joong-Gook Yang, Dong-Jin Kim, Young-Shin Yoo, Mi-Ae Aging Cell Original Articles Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the study of stem cell renewal and aging. Here we describe an age-related increase in the number and activity of intestinal stem cells (ISCs) and progenitor cells in Drosophila midgut. We determined that oxidative stress, induced by paraquat treatment or loss of catalase function, mimicked the changes associated with aging in the midgut. Furthermore, we discovered an age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations. Taken together, our findings suggest that PDGF/VEGF may play a central role in age-related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells. Blackwell Publishing Ltd 2008-06 /pmc/articles/PMC2408640/ /pubmed/18284659 http://dx.doi.org/10.1111/j.1474-9726.2008.00380.x Text en © The Authors Journal compilation © Blackwell Publishing Ltd/The Anatomical Society of Great Britain and Ireland 2008 https://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2·5, which does not permit commercial exploitation.
spellingShingle Original Articles
Choi, Na-Hyun
Kim, Joong-Gook
Yang, Dong-Jin
Kim, Young-Shin
Yoo, Mi-Ae
Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
title Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
title_full Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
title_fullStr Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
title_full_unstemmed Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
title_short Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
title_sort age-related changes in drosophila midgut are associated with pvf2, a pdgf/vegf-like growth factor
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408640/
https://www.ncbi.nlm.nih.gov/pubmed/18284659
http://dx.doi.org/10.1111/j.1474-9726.2008.00380.x
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