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Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies
Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARγ is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, w...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408681/ https://www.ncbi.nlm.nih.gov/pubmed/18528522 http://dx.doi.org/10.1155/2008/834612 |
| _version_ | 1782155699125485568 |
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| author | Garcia-Bates, Tatiana M. Lehmann, Geniece M. Simpson-Haidaris, Patricia J. Bernstein, Steven H. Sime, Patricia J. Phipps, Richard P. |
| author_facet | Garcia-Bates, Tatiana M. Lehmann, Geniece M. Simpson-Haidaris, Patricia J. Bernstein, Steven H. Sime, Patricia J. Phipps, Richard P. |
| author_sort | Garcia-Bates, Tatiana M. |
| collection | PubMed |
| description | Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARγ is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPARγ ligands influence hematological malignant cell growth, differentiation, and survival. Understanding the diverse properties of PPARγ ligands is crucial for the development of new therapeutic approaches for hematological malignancies. |
| format | Text |
| id | pubmed-2408681 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | Hindawi Publishing Corporation |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-24086812008-06-04 Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies Garcia-Bates, Tatiana M. Lehmann, Geniece M. Simpson-Haidaris, Patricia J. Bernstein, Steven H. Sime, Patricia J. Phipps, Richard P. PPAR Res Review Article Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARγ is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPARγ ligands influence hematological malignant cell growth, differentiation, and survival. Understanding the diverse properties of PPARγ ligands is crucial for the development of new therapeutic approaches for hematological malignancies. Hindawi Publishing Corporation 2008 2008-05-26 /pmc/articles/PMC2408681/ /pubmed/18528522 http://dx.doi.org/10.1155/2008/834612 Text en Copyright © 2008 Tatiana M. Garcia-Bates et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Article Garcia-Bates, Tatiana M. Lehmann, Geniece M. Simpson-Haidaris, Patricia J. Bernstein, Steven H. Sime, Patricia J. Phipps, Richard P. Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies |
| title | Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies |
| title_full | Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies |
| title_fullStr | Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies |
| title_full_unstemmed | Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies |
| title_short | Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies |
| title_sort | role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies |
| topic | Review Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408681/ https://www.ncbi.nlm.nih.gov/pubmed/18528522 http://dx.doi.org/10.1155/2008/834612 |
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