Effect of c-Abl tyrosine kinase on the cellular response to paclitaxel-induced microtubule damage

DNA damage has been shown to activate c-Abl tyrosine kinase. We now report that, in addition to DNA damage, microtubule damage induced by paclitaxel results in activation of c-Abl kinase. In 3T3 cells, the presence of c-Abl kinase increased paclitaxel-induced cell death. In Abl-proficient cells, pac...

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Detalles Bibliográficos
Autores principales: Nehmé, A, Lee, B L, Baskaran, R, Zhang, Q, Lin, X, Christen, R D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408779/
https://www.ncbi.nlm.nih.gov/pubmed/11044362
http://dx.doi.org/10.1054/bjoc.2000.1440

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