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Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis
The role of Msh2 in chromosome stability has been investigated in a targeted mouse model for HNPCC Msh2Δ7N. Chromosome aberration frequencies were similar in bone marrow of Msh2(+/+)Msh2(+/–)and Msh2(–/–)mice and no differential effects of in vivo X-irradiation were noted. By contrast, the induction...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2000
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408782/ https://www.ncbi.nlm.nih.gov/pubmed/11044352 http://dx.doi.org/10.1054/bjoc.2000.1422 |