Cargando…

Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status

p53 tumour-suppressor gene is involved in cell growth control, arrest and apoptosis. Nevertheless cell cycle arrest and apoptosis induction can be observed in p53-defective cells after exposure to DNA-damaging agents such as 5-fluorouracil (5-FU) suggesting the importance of alternative pathways via...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mirjolet, J-F, Barberi-Heyob, M, Didelot, C, Peyrat, J-P, Abecassis, J, Millon, R, Merlin, J-L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408783/ https://www.ncbi.nlm.nih.gov/pubmed/11044365 http://dx.doi.org/10.1054/bjoc.2000.1455

Ejemplares similares

Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.
por: Mirjolet, J. F., et al.
Publicado: (1998)

Prostate tumours from an Asian population: examination of bax, bcl-2, p53 and ras and identification of bax as prognostic marker
por: Chia, S-J, et al.
Publicado: (2000)

Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity
por: Milano, G, et al.
Publicado: (1999)

Reduced expression of BAX is associated with poor prognosis in patients with epithelial ovarian cancer: a multifactorial analysis of TP53, p21, BAX and BCL-2
por: Schuyer, M, et al.
Publicado: (2001)

The prognostic significance of apoptosis-associated proteins BCL-2, BAX and BCL-X in clinical nephroblastoma
por: Ghanem, M A, et al.
Publicado: (2001)

Mitigation of apoptosis-mediated neurotoxicity induced by silver nanoparticles via rutaceae nutraceuticals: P53 activation and Bax/Bcl-2 regulation
por: Abdel-Megeed, Rehab M., et al.
Publicado: (2022)

Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia
por: Vucicevic, Ksenija, et al.
Publicado: (2016)

Bax/Bcl-2 expression ratio in prediction of response to breast cancer radiotherapy
por: Azimian, Hosein, et al.
Publicado: (2018)

The Action of Bax and Bcl-2 on T Cell Selection
por: Williams, Owen, et al.
Publicado: (1998)

Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance.
por: Williamson, K. E., et al.
Publicado: (1998)

Regulated Targeting of BAX to Mitochondria
por: Goping, Ing Swie, et al.
Publicado: (1998)

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
por: Kulsoom, Bibi, et al.
Publicado: (2018)

Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts
por: Escobar, Enrico, et al.
Publicado: (2023)

Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2/Bax and Bcl-xL/Bax ratios and reducing reactive gliosis
por: Fan, Yichao, et al.
Publicado: (2014)

Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines.
por: Burger, H., et al.
Publicado: (1998)

Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio
por: Sharifah Sakinah, SA, et al.
Publicado: (2007)

Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance.
por: Pepper, C., et al.
Publicado: (1997)

PB1821: THE INFLUENCE OF BCL2, BAX, BAX/BCL2 RATIO AND MDR1 GENE EXPRESSION ON PROGNOSIS OF ADULT DE NOVO ACUTE MYELOID LEUKEMIA PATIENTS WITH NORMAL KARYOTYPE
por: Pravdic, Zlatko, et al.
Publicado: (2023)

Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX
por: Nehls, O, et al.
Publicado: (2007)

Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical responsiveness - reply
por: Bentley, P, et al.
Publicado: (1998)

Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with Age and Tumor Location in Colorectal Cancer?
por: Khodapasand, Ehsan, et al.
Publicado: (2015)

Photodynamic Therapy Using a Novel Phosphorus Tetraphenylporphyrin Induces an Anticancer Effect via Bax/Bcl-xL-related Mitochondrial Apoptosis in Biliary Cancer Cells
por: Mai, Nguyen Nhat Huynh, et al.
Publicado: (2020)

Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax
por: Tenório, Jefferson-da Rocha, et al.
Publicado: (2018)

Early and late apoptosis protein expression (Bcl-2, BAX and p53) in traumatic brachial plexus injury
por: Suroto, Heri, et al.
Publicado: (2021)

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax
por: Billen, Lieven P, et al.
Publicado: (2008)

Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen
por: Kupryjańczyk, J, et al.
Publicado: (2003)

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg(2+) Ions
por: Eskes, Robert, et al.
Publicado: (1998)

Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer
por: Borner, M M, et al.
Publicado: (1999)

The Effect of Arbutin on The Expression of Tumor Suppressor P53, BAX/BCL-2 Ratio and Oxidative Stress Induced by Tert-Butyl Hydroperoxide in Fibroblast and LNcap Cell Lines
por: Ebadollahi, Shima, et al.
Publicado: (2021)

Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers
por: Nazim, Uddin MD., et al.
Publicado: (2017)

Enhanced levels of the apoptotic BAX/BCL-2 ratio in children with acute lymphoblastic leukemia and high-risk features
por: Kaparou, Maria, et al.
Publicado: (2013)

Heartwood extract of Acacia catechu induces apoptosis in human breast carcinoma by altering bax/bcl-2 ratio
por: Ghate, Nikhil Baban, et al.
Publicado: (2014)

The effect of moderate exercise on the elevation of Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene
por: Irmawati, Anis, et al.
Publicado: (2018)

Expression of the novel tumour suppressor p33(ING1) is independent of p53
por: Cheung, K-J J, et al.
Publicado: (2000)

The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells
por: Han, Ji-Youn, et al.
Publicado: (1999)

miR-21 regulates ischemic neuronal injury via the p53/Bcl-2/Bax signaling pathway
por: Yan, Honglin, et al.
Publicado: (2021)

Oxaliplatin and protracted venous infusion of 5-fluorouracil in patients with advanced or relapsed 5-fluorouracil pretreated colorectal cancer
por: Chau, I, et al.
Publicado: (2001)

Expression of Apoptotic Markers Bcl-2 and Bax in the Vascular Wall
por: Klimentova, E.A., et al.
Publicado: (2021)

Exhaustive Training Increases Uncoupling Protein 2 Expression and Decreases Bcl-2/Bax Ratio in Rat Skeletal Muscle
por: Liu, W. Y., et al.
Publicado: (2013)

Emodin inhibits LOVO colorectal cancer cell proliferation via the regulation of the Bcl-2/Bax ratio and cytochrome c
por: MA, LIANG, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9td5hdibs5t5ju4eigk002jfee