Cargando…
Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression
Differential diagnosis between keratoacanthomas and well differentiated squamous cell carcinomas based on clinical and histomorphological data is problematic. Recent findings of cellular atypia in a large proportion of keratoacanthomas indicated that these potentially ‘self-healing’ cutaneous neopla...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2002
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408913/ https://www.ncbi.nlm.nih.gov/pubmed/12439721 http://dx.doi.org/10.1038/sj.bjc.6600622 |
_version_ | 1782155720791162880 |
---|---|
author | Strieth, S Hartschuh, W Pilz, L Fusenig, N E |
author_facet | Strieth, S Hartschuh, W Pilz, L Fusenig, N E |
author_sort | Strieth, S |
collection | PubMed |
description | Differential diagnosis between keratoacanthomas and well differentiated squamous cell carcinomas based on clinical and histomorphological data is problematic. Recent findings of cellular atypia in a large proportion of keratoacanthomas indicated that these potentially ‘self-healing’ cutaneous neoplasms had the potential for malignant progression. Another malignancy-associated criterion is enhanced angiogenesis with increased microvessel density. To provide further diagnostic markers for keratoacanthomas we examined microvessel density on paraffin sections of 13 keratoacanthomas in comparison with 10 normal skin biopsies and 16 late-stage skin squamous cell carcinomas by counting and by computer-assisted image analysis of CD31-immunostained vessels. A significant increase of microvessel density in ‘hot spots’ was observed in keratoacanthomas as compared to normal skin. Furthermore, when keratoacanthomas were subdivided into tumours with and without malignancy-associated atypic areas, only those with atypia (n=6) were significantly better vascularised than normal skin and had a mean microvessel density in the range of late-stage squamous cell carcinomas. Both keratoacanthoma subtypes revealed comparable levels of inflammatory cell infiltration, tumour cell proliferation and vascular endothelial growth factor expression (mRNA and protein). Thus, in addition to malignancy-associated cellular atypia, increased microvessel density may serve as further diagnostic parameter to discriminate keratoacanthomas with a potential to progress to malignancy. British Journal of Cancer (2002) 87, 1301–1307. doi:10.1038/sj.bjc.6600622 www.bjcancer.com © 2002 Cancer Research UK |
format | Text |
id | pubmed-2408913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-24089132009-09-10 Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression Strieth, S Hartschuh, W Pilz, L Fusenig, N E Br J Cancer Molecular and Cellular Pathology Differential diagnosis between keratoacanthomas and well differentiated squamous cell carcinomas based on clinical and histomorphological data is problematic. Recent findings of cellular atypia in a large proportion of keratoacanthomas indicated that these potentially ‘self-healing’ cutaneous neoplasms had the potential for malignant progression. Another malignancy-associated criterion is enhanced angiogenesis with increased microvessel density. To provide further diagnostic markers for keratoacanthomas we examined microvessel density on paraffin sections of 13 keratoacanthomas in comparison with 10 normal skin biopsies and 16 late-stage skin squamous cell carcinomas by counting and by computer-assisted image analysis of CD31-immunostained vessels. A significant increase of microvessel density in ‘hot spots’ was observed in keratoacanthomas as compared to normal skin. Furthermore, when keratoacanthomas were subdivided into tumours with and without malignancy-associated atypic areas, only those with atypia (n=6) were significantly better vascularised than normal skin and had a mean microvessel density in the range of late-stage squamous cell carcinomas. Both keratoacanthoma subtypes revealed comparable levels of inflammatory cell infiltration, tumour cell proliferation and vascular endothelial growth factor expression (mRNA and protein). Thus, in addition to malignancy-associated cellular atypia, increased microvessel density may serve as further diagnostic parameter to discriminate keratoacanthomas with a potential to progress to malignancy. British Journal of Cancer (2002) 87, 1301–1307. doi:10.1038/sj.bjc.6600622 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-11-18 2002-11-12 /pmc/articles/PMC2408913/ /pubmed/12439721 http://dx.doi.org/10.1038/sj.bjc.6600622 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Molecular and Cellular Pathology Strieth, S Hartschuh, W Pilz, L Fusenig, N E Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression |
title | Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression |
title_full | Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression |
title_fullStr | Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression |
title_full_unstemmed | Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression |
title_short | Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression |
title_sort | carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression |
topic | Molecular and Cellular Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408913/ https://www.ncbi.nlm.nih.gov/pubmed/12439721 http://dx.doi.org/10.1038/sj.bjc.6600622 |
work_keys_str_mv | AT strieths carcinomalikevasculardensityinatypickeratoacanthomasuggestsmalignantprogression AT hartschuhw carcinomalikevasculardensityinatypickeratoacanthomasuggestsmalignantprogression AT pilzl carcinomalikevasculardensityinatypickeratoacanthomasuggestsmalignantprogression AT fusenigne carcinomalikevasculardensityinatypickeratoacanthomasuggestsmalignantprogression |