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MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis
Recent study in a group of German patients with SSc has implicated the SNP in the MCP-1 gene (−2518 A to G) as a factor of susceptibility to SSc. Reflecting the need for replication of genetic association studies, we investigated if this SNP is associated with SSc in another Caucasian population. MC...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408933/ https://www.ncbi.nlm.nih.gov/pubmed/18528529 http://dx.doi.org/10.1155/2008/204063 |
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author | Navratilova, Zdenka Lukac, Jozef Mrazek, Frantisek Kriegova, Eva Bucova, Maria Bosak, Vladimir Petrek, Martin |
author_facet | Navratilova, Zdenka Lukac, Jozef Mrazek, Frantisek Kriegova, Eva Bucova, Maria Bosak, Vladimir Petrek, Martin |
author_sort | Navratilova, Zdenka |
collection | PubMed |
description | Recent study in a group of German patients with SSc has implicated the SNP in the MCP-1 gene (−2518 A to G) as a factor of susceptibility to SSc. Reflecting the need for replication of genetic association studies, we investigated if this SNP is associated with SSc in another Caucasian population. MCP-1 −2518 A/G genotypes were determined using PCR-SSP in 46 SSc patients and in 449 healthy subjects, all unrelated and of Slovak (Slavonic) origin. The distribution of MCP-1 −2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. There was no difference in MCP-1 −2518*G allele frequency between SSc patients and healthy subjects (patients: 0.23; controls: 0.24; P > .05). Furthermore, MCP-1 −2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (P > .05). The association of MCP-1 −2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population. |
format | Text |
id | pubmed-2408933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-24089332008-06-04 MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis Navratilova, Zdenka Lukac, Jozef Mrazek, Frantisek Kriegova, Eva Bucova, Maria Bosak, Vladimir Petrek, Martin Mediators Inflamm Clinical Study Recent study in a group of German patients with SSc has implicated the SNP in the MCP-1 gene (−2518 A to G) as a factor of susceptibility to SSc. Reflecting the need for replication of genetic association studies, we investigated if this SNP is associated with SSc in another Caucasian population. MCP-1 −2518 A/G genotypes were determined using PCR-SSP in 46 SSc patients and in 449 healthy subjects, all unrelated and of Slovak (Slavonic) origin. The distribution of MCP-1 −2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. There was no difference in MCP-1 −2518*G allele frequency between SSc patients and healthy subjects (patients: 0.23; controls: 0.24; P > .05). Furthermore, MCP-1 −2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (P > .05). The association of MCP-1 −2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population. Hindawi Publishing Corporation 2008 2008-06-02 /pmc/articles/PMC2408933/ /pubmed/18528529 http://dx.doi.org/10.1155/2008/204063 Text en Copyright © 2008 Zdenka Navratilova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Navratilova, Zdenka Lukac, Jozef Mrazek, Frantisek Kriegova, Eva Bucova, Maria Bosak, Vladimir Petrek, Martin MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis |
title | MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis |
title_full | MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis |
title_fullStr | MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis |
title_full_unstemmed | MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis |
title_short | MCP-1 −2518 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis |
title_sort | mcp-1 −2518 a/g single nucleotide polymorphism in slovak patients with systemic sclerosis |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408933/ https://www.ncbi.nlm.nih.gov/pubmed/18528529 http://dx.doi.org/10.1155/2008/204063 |
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