HDAC Inhibitors Act with 5-aza-2′-Deoxycytidine to Inhibit Cell Proliferation by Suppressing Removal of Incorporated Abases in Lung Cancer Cells

5-aza-2′-deoxycytidine (5-aza-CdR) is used extensively as a demethylating agent and acts in concert with histone deacetylase inhibitors (HDACI) to induce apoptosis or inhibition of cell proliferation in human cancer cells. Whether the action of 5-aza-CdR in this synergistic effect results from demet...

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Detalles Bibliográficos
Autores principales: Chai, Guolin, Li, Lian, Zhou, Wen, Wu, Lipeng, Zhao, Ying, Wang, Donglai, Lu, Shaoli, Yu, Yu, Wang, Haiying, McNutt, Michael A., Hu, Ye-Guang, Chen, Yingqi, Yang, Yang, Wu, Xin, Otterson, Gregory A., Zhu, Wei-Guo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409077/
https://www.ncbi.nlm.nih.gov/pubmed/18560576
http://dx.doi.org/10.1371/journal.pone.0002445

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