Cargando…
Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis. In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhi...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409342/ https://www.ncbi.nlm.nih.gov/pubmed/18489786 http://dx.doi.org/10.1186/1471-2180-8-78 |