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Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report
BACKGROUND: Superficial leiomyosarcoma is an exceedingly uncommon malignant tumor which could be located either to cutaneous or subcutaneous tissues. Increased mass size and depth, advanced tumor staging and inadequate surgical excision are the main prognostic factors for poor result. CASE PRESENTAT...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409359/ https://www.ncbi.nlm.nih.gov/pubmed/18495007 http://dx.doi.org/10.1186/1477-7800-5-11 |
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author | Angeloni, Marina Muratori, Francesco Magarelli, Nicola Chalidis, Byron E Ricci, Riccardo Rossi, Barbara Maccauro, Giulio |
author_facet | Angeloni, Marina Muratori, Francesco Magarelli, Nicola Chalidis, Byron E Ricci, Riccardo Rossi, Barbara Maccauro, Giulio |
author_sort | Angeloni, Marina |
collection | PubMed |
description | BACKGROUND: Superficial leiomyosarcoma is an exceedingly uncommon malignant tumor which could be located either to cutaneous or subcutaneous tissues. Increased mass size and depth, advanced tumor staging and inadequate surgical excision are the main prognostic factors for poor result. CASE PRESENTATION: We report a rare case of a 71-year-old man with an extensive exophytic lesion (12 × 10 cm) in the anterior-medial side of the proximal right tibia. The lesion was painless and consistently neglected by the patient until a skin trauma caused ulceration of the affected area. Magnetic Resonance Imaging revealed a soft-tissue mass which was well defined from the surrounding bone and muscles. As initial biopsy in another hospital hadn't clarified the true nature of the lesion, new samples were taken and the diagnosis of leiomyosarcoma was established. Laboratory examination showed no distant metastasis and wide excision of the neoplasm was decided. After tumor resection, the remaining soft tissue and skin defect was covered with a gastrocnemius myocutaneous flap. The postoperative period was uneventful and wound healing was followed by local radiotherapy and systemic chemotherapy. At 3 years follow up, no recurrence or metastasis was identified and the patient was able to walk and stand without impairment of his ambulatory status. CONCLUSION: Proper surgical management of soft tissue leiomyosarcoma continues to remain the cornerstone of treatment efficacy and the most important prognostic factor for patients' survival. Reconstruction of the remaining soft tissue defect should be always performed at the same operative time when removal of giant size tumors leaves an uncovered cavity with an inadequate sleeve of muscular and skin tissues. |
format | Text |
id | pubmed-2409359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-24093592008-06-04 Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report Angeloni, Marina Muratori, Francesco Magarelli, Nicola Chalidis, Byron E Ricci, Riccardo Rossi, Barbara Maccauro, Giulio Int Semin Surg Oncol Case Report BACKGROUND: Superficial leiomyosarcoma is an exceedingly uncommon malignant tumor which could be located either to cutaneous or subcutaneous tissues. Increased mass size and depth, advanced tumor staging and inadequate surgical excision are the main prognostic factors for poor result. CASE PRESENTATION: We report a rare case of a 71-year-old man with an extensive exophytic lesion (12 × 10 cm) in the anterior-medial side of the proximal right tibia. The lesion was painless and consistently neglected by the patient until a skin trauma caused ulceration of the affected area. Magnetic Resonance Imaging revealed a soft-tissue mass which was well defined from the surrounding bone and muscles. As initial biopsy in another hospital hadn't clarified the true nature of the lesion, new samples were taken and the diagnosis of leiomyosarcoma was established. Laboratory examination showed no distant metastasis and wide excision of the neoplasm was decided. After tumor resection, the remaining soft tissue and skin defect was covered with a gastrocnemius myocutaneous flap. The postoperative period was uneventful and wound healing was followed by local radiotherapy and systemic chemotherapy. At 3 years follow up, no recurrence or metastasis was identified and the patient was able to walk and stand without impairment of his ambulatory status. CONCLUSION: Proper surgical management of soft tissue leiomyosarcoma continues to remain the cornerstone of treatment efficacy and the most important prognostic factor for patients' survival. Reconstruction of the remaining soft tissue defect should be always performed at the same operative time when removal of giant size tumors leaves an uncovered cavity with an inadequate sleeve of muscular and skin tissues. BioMed Central 2008-05-21 /pmc/articles/PMC2409359/ /pubmed/18495007 http://dx.doi.org/10.1186/1477-7800-5-11 Text en Copyright © 2008 Angeloni et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Angeloni, Marina Muratori, Francesco Magarelli, Nicola Chalidis, Byron E Ricci, Riccardo Rossi, Barbara Maccauro, Giulio Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report |
title | Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report |
title_full | Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report |
title_fullStr | Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report |
title_full_unstemmed | Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report |
title_short | Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report |
title_sort | exophytic growth of a neglected giant subcutaneous leiomyosarcoma of the lower extremity. a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409359/ https://www.ncbi.nlm.nih.gov/pubmed/18495007 http://dx.doi.org/10.1186/1477-7800-5-11 |
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