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Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade

The role of the DNA double-strand-break (DSB) checkpoint/repair genes, ATM, BRCA1 and TP53, in sporadic breast cancer requires clarification, since ATM and BRCA1 mutations are rare in sporadic tumours. In an attempt to explain this phenomenon, we postulated that (i) in addition to genetic deletion,...

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Detalles Bibliográficos
Autores principales:	Ding, S L, Sheu, L F, Yu, J C, Yang, T L, Chen, B F, Leu, F J, Shen, C Y
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409464/ https://www.ncbi.nlm.nih.gov/pubmed/15138484 http://dx.doi.org/10.1038/sj.bjc.6601804

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