The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma

Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the me...

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Autores principales: Linnebank, M, Schmidt, S, Kolsch, H, Linnebank, A, Heun, R, Schmidt-Wolf, I G H, Glasmacher, A, Fliessbach, K, Klockgether, T, Schlegel, U, Pels, H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409477/
https://www.ncbi.nlm.nih.gov/pubmed/15138479
http://dx.doi.org/10.1038/sj.bjc.6601777
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author Linnebank, M
Schmidt, S
Kolsch, H
Linnebank, A
Heun, R
Schmidt-Wolf, I G H
Glasmacher, A
Fliessbach, K
Klockgether, T
Schlegel, U
Pels, H
author_facet Linnebank, M
Schmidt, S
Kolsch, H
Linnebank, A
Heun, R
Schmidt-Wolf, I G H
Glasmacher, A
Fliessbach, K
Klockgether, T
Schlegel, U
Pels, H
author_sort Linnebank, M
collection PubMed
description Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09–0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis.
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spelling pubmed-24094772009-09-10 The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma Linnebank, M Schmidt, S Kolsch, H Linnebank, A Heun, R Schmidt-Wolf, I G H Glasmacher, A Fliessbach, K Klockgether, T Schlegel, U Pels, H Br J Cancer Genetics and Genomics Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09–0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis. Nature Publishing Group 2004-05-17 2004-04-06 /pmc/articles/PMC2409477/ /pubmed/15138479 http://dx.doi.org/10.1038/sj.bjc.6601777 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Linnebank, M
Schmidt, S
Kolsch, H
Linnebank, A
Heun, R
Schmidt-Wolf, I G H
Glasmacher, A
Fliessbach, K
Klockgether, T
Schlegel, U
Pels, H
The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
title The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
title_full The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
title_fullStr The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
title_full_unstemmed The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
title_short The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
title_sort methionine synthase polymorphism d919g alters susceptibility to primary central nervous system lymphoma
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409477/
https://www.ncbi.nlm.nih.gov/pubmed/15138479
http://dx.doi.org/10.1038/sj.bjc.6601777
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