Total body irradiation and pneumonitis risk: a review of outcomes

A review was undertaken of all patients treated at Royal Adelaide Hospital, South Australia with total body irradiation (TBI) for the purpose of assessing the incidence of interstitial pneumonitis (IP) and possible prognostic factors for its development. The aim was also to assess the impact of IP a...

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Detalles Bibliográficos
Autores principales: Carruthers, S A, Wallington, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409505/
https://www.ncbi.nlm.nih.gov/pubmed/15150598
http://dx.doi.org/10.1038/sj.bjc.6601751
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author Carruthers, S A
Wallington, M M
author_facet Carruthers, S A
Wallington, M M
author_sort Carruthers, S A
collection PubMed
description A review was undertaken of all patients treated at Royal Adelaide Hospital, South Australia with total body irradiation (TBI) for the purpose of assessing the incidence of interstitial pneumonitis (IP) and possible prognostic factors for its development. The aim was also to assess the impact of IP and other prognostic factors on long-term survival outcome following bone marrow transplantation. A total of 84 patients received TBI, with 12 Gy in six fractions delivered using two different instantaneous dose rates of 7.5 and 15 cGy min(−1). This series included 26 cases of acute lymphoblastic leukaemia, 26 of multiple myeloma and 15 of acute myelogenous leukaemia. On multivariate analysis, a higher dose rate was independently significant for an increased risk of IP.
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spelling pubmed-24095052009-09-10 Total body irradiation and pneumonitis risk: a review of outcomes Carruthers, S A Wallington, M M Br J Cancer Clinical A review was undertaken of all patients treated at Royal Adelaide Hospital, South Australia with total body irradiation (TBI) for the purpose of assessing the incidence of interstitial pneumonitis (IP) and possible prognostic factors for its development. The aim was also to assess the impact of IP and other prognostic factors on long-term survival outcome following bone marrow transplantation. A total of 84 patients received TBI, with 12 Gy in six fractions delivered using two different instantaneous dose rates of 7.5 and 15 cGy min(−1). This series included 26 cases of acute lymphoblastic leukaemia, 26 of multiple myeloma and 15 of acute myelogenous leukaemia. On multivariate analysis, a higher dose rate was independently significant for an increased risk of IP. Nature Publishing Group 2004-06-01 2004-05-04 /pmc/articles/PMC2409505/ /pubmed/15150598 http://dx.doi.org/10.1038/sj.bjc.6601751 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Carruthers, S A
Wallington, M M
Total body irradiation and pneumonitis risk: a review of outcomes
title Total body irradiation and pneumonitis risk: a review of outcomes
title_full Total body irradiation and pneumonitis risk: a review of outcomes
title_fullStr Total body irradiation and pneumonitis risk: a review of outcomes
title_full_unstemmed Total body irradiation and pneumonitis risk: a review of outcomes
title_short Total body irradiation and pneumonitis risk: a review of outcomes
title_sort total body irradiation and pneumonitis risk: a review of outcomes
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409505/
https://www.ncbi.nlm.nih.gov/pubmed/15150598
http://dx.doi.org/10.1038/sj.bjc.6601751
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AT wallingtonmm totalbodyirradiationandpneumonitisriskareviewofoutcomes

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