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Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients
In the present study, we investigated whether age and serious comorbid conditions influence treatment decisions, complications and survival in breast cancer patients. The Eindhoven Cancer Registry records patient, tumour and therapy characteristics of all patients diagnosed with cancer in the southe...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409529/ https://www.ncbi.nlm.nih.gov/pubmed/15162155 http://dx.doi.org/10.1038/sj.bjc.6601844 |
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author | Houterman, S Janssen-Heijnen, M L G Verheij, C D G W Louwman, W J Vreugdenhil, G van der Sangen, M J C Coebergh, J W W |
author_facet | Houterman, S Janssen-Heijnen, M L G Verheij, C D G W Louwman, W J Vreugdenhil, G van der Sangen, M J C Coebergh, J W W |
author_sort | Houterman, S |
collection | PubMed |
description | In the present study, we investigated whether age and serious comorbid conditions influence treatment decisions, complications and survival in breast cancer patients. The Eindhoven Cancer Registry records patient, tumour and therapy characteristics of all patients diagnosed with cancer in the southern part of the Netherlands. Additional information on severity of comorbidity and serious complications was collected for a random sample of 527 breast cancer patients (aged 40 years and older). More than 70% of the patients ⩾80 exhibited high severity of comorbidity compared to 6% of those aged 40–49 years. Treatment was not influenced by severity of comorbidity. Less than 30% of the breast cancer patients had complications after diagnosis. The number of complications was not related to age or severity of comorbidity. The hazard ratio (HR) of dying for patients with low/moderate severity of comorbidity was 2.4 for those aged 40–69 years and 1.6 for those aged ⩾70 years, after adjustment for age, nodal status and treatment. For patients with high severity of comorbidity, the risk of dying was almost three times higher. Older breast cancer patients with serious comorbidity were not treated differently and did not have more complications compared to those without comorbidity, but they exhibited a worse prognosis. |
format | Text |
id | pubmed-2409529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-24095292009-09-10 Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients Houterman, S Janssen-Heijnen, M L G Verheij, C D G W Louwman, W J Vreugdenhil, G van der Sangen, M J C Coebergh, J W W Br J Cancer Clinical In the present study, we investigated whether age and serious comorbid conditions influence treatment decisions, complications and survival in breast cancer patients. The Eindhoven Cancer Registry records patient, tumour and therapy characteristics of all patients diagnosed with cancer in the southern part of the Netherlands. Additional information on severity of comorbidity and serious complications was collected for a random sample of 527 breast cancer patients (aged 40 years and older). More than 70% of the patients ⩾80 exhibited high severity of comorbidity compared to 6% of those aged 40–49 years. Treatment was not influenced by severity of comorbidity. Less than 30% of the breast cancer patients had complications after diagnosis. The number of complications was not related to age or severity of comorbidity. The hazard ratio (HR) of dying for patients with low/moderate severity of comorbidity was 2.4 for those aged 40–69 years and 1.6 for those aged ⩾70 years, after adjustment for age, nodal status and treatment. For patients with high severity of comorbidity, the risk of dying was almost three times higher. Older breast cancer patients with serious comorbidity were not treated differently and did not have more complications compared to those without comorbidity, but they exhibited a worse prognosis. Nature Publishing Group 2004-06-14 2004-05-25 /pmc/articles/PMC2409529/ /pubmed/15162155 http://dx.doi.org/10.1038/sj.bjc.6601844 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Houterman, S Janssen-Heijnen, M L G Verheij, C D G W Louwman, W J Vreugdenhil, G van der Sangen, M J C Coebergh, J W W Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients |
title | Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients |
title_full | Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients |
title_fullStr | Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients |
title_full_unstemmed | Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients |
title_short | Comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients |
title_sort | comorbidity has negligible impact on treatment and complications but influences survival in breast cancer patients |
topic | Clinical |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409529/ https://www.ncbi.nlm.nih.gov/pubmed/15162155 http://dx.doi.org/10.1038/sj.bjc.6601844 |
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