Conferring specificity on the ubiquitous Raf/MEK signalling pathway

The Raf-MEK-ERK signalling pathway controls fundamental cellular processes including proliferation, differentiation and survival. It remains enigmatic how this pathway can reliably convert a myriad of extracellular stimuli in specific biological responses. Recent results have shown that the Raf fami...

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Detalles Bibliográficos
Autores principales: O'Neill, E, Kolch, W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409554/
https://www.ncbi.nlm.nih.gov/pubmed/14735164
http://dx.doi.org/10.1038/sj.bjc.6601488
Descripción
Sumario:The Raf-MEK-ERK signalling pathway controls fundamental cellular processes including proliferation, differentiation and survival. It remains enigmatic how this pathway can reliably convert a myriad of extracellular stimuli in specific biological responses. Recent results have shown that the Raf family isoforms A-Raf, B-Raf and Raf-1 have different physiological functions. Here we review how Raf isozyme diversity contributes to the specification of functional diversity, in particular regarding the role of Raf isozymes in cancer.

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