Conferring specificity on the ubiquitous Raf/MEK signalling pathway

The Raf-MEK-ERK signalling pathway controls fundamental cellular processes including proliferation, differentiation and survival. It remains enigmatic how this pathway can reliably convert a myriad of extracellular stimuli in specific biological responses. Recent results have shown that the Raf fami...

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Detalles Bibliográficos
Autores principales: O'Neill, E, Kolch, W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409554/
https://www.ncbi.nlm.nih.gov/pubmed/14735164
http://dx.doi.org/10.1038/sj.bjc.6601488
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author O'Neill, E
Kolch, W
author_facet O'Neill, E
Kolch, W
author_sort O'Neill, E
collection PubMed
description The Raf-MEK-ERK signalling pathway controls fundamental cellular processes including proliferation, differentiation and survival. It remains enigmatic how this pathway can reliably convert a myriad of extracellular stimuli in specific biological responses. Recent results have shown that the Raf family isoforms A-Raf, B-Raf and Raf-1 have different physiological functions. Here we review how Raf isozyme diversity contributes to the specification of functional diversity, in particular regarding the role of Raf isozymes in cancer.
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spelling pubmed-24095542009-09-10 Conferring specificity on the ubiquitous Raf/MEK signalling pathway O'Neill, E Kolch, W Br J Cancer Minireview The Raf-MEK-ERK signalling pathway controls fundamental cellular processes including proliferation, differentiation and survival. It remains enigmatic how this pathway can reliably convert a myriad of extracellular stimuli in specific biological responses. Recent results have shown that the Raf family isoforms A-Raf, B-Raf and Raf-1 have different physiological functions. Here we review how Raf isozyme diversity contributes to the specification of functional diversity, in particular regarding the role of Raf isozymes in cancer. Nature Publishing Group 2004-01-26 2004-01-20 /pmc/articles/PMC2409554/ /pubmed/14735164 http://dx.doi.org/10.1038/sj.bjc.6601488 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
O'Neill, E
Kolch, W
Conferring specificity on the ubiquitous Raf/MEK signalling pathway
title Conferring specificity on the ubiquitous Raf/MEK signalling pathway
title_full Conferring specificity on the ubiquitous Raf/MEK signalling pathway
title_fullStr Conferring specificity on the ubiquitous Raf/MEK signalling pathway
title_full_unstemmed Conferring specificity on the ubiquitous Raf/MEK signalling pathway
title_short Conferring specificity on the ubiquitous Raf/MEK signalling pathway
title_sort conferring specificity on the ubiquitous raf/mek signalling pathway
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409554/
https://www.ncbi.nlm.nih.gov/pubmed/14735164
http://dx.doi.org/10.1038/sj.bjc.6601488
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AT kolchw conferringspecificityontheubiquitousrafmeksignallingpathway

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