Cargando…

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity

The relationship of thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on 5-fluorouracil (FU) sensitivity was tested on 19 human cancer cell lines (head and neck, breast, digestive tract) in the absence and presence of folinic acid (FA) supplementation. Thym...

Descripción completa

Detalles Bibliográficos
Autores principales:	Etienne, M-C, Ilc, K, Formento, J-L, Laurent-Puig, P, Formento, P, Cheradame, S, Fischel, J-L, Milano, G
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409555/ https://www.ncbi.nlm.nih.gov/pubmed/14735204 http://dx.doi.org/10.1038/sj.bjc.6601523

Ejemplares similares

Impact of the oxaliplatin-5 fluorouracil-folinic acid combination on respective intracellular determinants of drug activity
por: Fischel, J L, et al.
Publicado: (2002)

Molecular mechanisms underlying the interaction between ZD1839 (‘Iressa’) and cisplatin/5-fluorouracil
por: Magné, N, et al.
Publicado: (2003)

Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Impact on cell growth and molecular factors
por: Fischel, J-L, et al.
Publicado: (2005)

Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 (‘Iressa’)
por: Magné, N, et al.
Publicado: (2002)

Enhanced tumour antiangiogenic effects when combining gefitinib with the antivascular agent ZD6126
por: Bozec, A, et al.
Publicado: (2006)

Sequence-dependent effects of ZD1839 (‘Iressa’) in combination with cytotoxic treatment in human head and neck cancer
por: Magné, N, et al.
Publicado: (2002)

A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil
por: Etienne, M C, et al.
Publicado: (1999)

Ternary combination of irinotecan, fluorouracil-folinic acid and oxaliplatin: results on human colon cancer cell lines
por: Fischel, J-L, et al.
Publicado: (2001)

Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.
por: Mirjolet, J. F., et al.
Publicado: (1998)

Critical factors for the reversal of methotrexate cytotoxicity by folinic acid.
por: Bernard, S., et al.
Publicado: (1991)

Dose reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. In vitro study on human head and neck carcinoma cell lines.
por: Etienne, M. C., et al.
Publicado: (1991)

Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: antitumour supra-additive effects on human head and neck cancer xenografts
por: Bozec, A, et al.
Publicado: (2007)

The Polymorphisms in Methylenetetrahydrofolate Reductase, Methionine Synthase, Methionine Synthase Reductase, and the Risk of Colorectal Cancer
por: Zhou, Daijun, et al.
Publicado: (2012)

Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines
por: Sekhon, J, et al.
Publicado: (2002)

Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure
por: Choi, Youngsok, et al.
Publicado: (2016)

Identification of thymidylate synthase as a potential therapeutic target for lung cancer
por: Takezawa, K, et al.
Publicado: (2010)

Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil
por: Ulrich, C M, et al.
Publicado: (2002)

Reply: Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil
por: Iacopetta, B, et al.
Publicado: (2002)

Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
por: Takezawa, K, et al.
Publicado: (2011)

Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome
por: Turgal, Mert, et al.
Publicado: (2018)

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels
por: Giovannetti, E, et al.
Publicado: (2007)

Pancytopenia and Severe Gastrointestinal Toxicities Associated with 5-Fluorouracil in a Patient with Thymidylate Synthase (TYMS) Polymorphism
por: Wang, Bo, et al.
Publicado: (2016)

Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy
por: Graziano, F, et al.
Publicado: (2008)

Tamoxifen metabolism: pharmacokinetic and in vitro study.
por: Etienne, M. C., et al.
Publicado: (1989)

Combined effects of bevacizumab with erlotinib and irradiation: a preclinical study on a head and neck cancer orthotopic model
por: Bozec, A, et al.
Publicado: (2008)

Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
por: Campbell, Ian G, et al.
Publicado: (2002)

Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia
por: KÜPELİ, Serhan
Publicado: (2015)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase
por: Asuncion Valenzuela, Malyn M, et al.
Publicado: (2015)

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
por: Begley, Darren W., et al.
Publicado: (2011)

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia
por: Figueroa-Torres, Anahi Guadalupe, et al.
Publicado: (2020)

Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-Fluorouracil
por: Kurasaka, Chinatsu, et al.
Publicado: (2022)

Prognostic Relevance of Methylenetetrahydrofolate Reductase Polymorphisms for Prostate Cancer
por: Lin, Victor C., et al.
Publicado: (2016)

Methylenetetrahydrofolate Reductase Polymorphism and Premature Coronary Artery Disease
por: Zaghloul, Ahmed, et al.
Publicado: (2019)

Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells
por: Wang, W, et al.
Publicado: (2003)

Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F
por: Le François, B G, et al.
Publicado: (2007)

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene
por: Tirakarn, Srisuda, et al.
Publicado: (2012)

Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
por: Chaianantakul, Natpasit, et al.
Publicado: (2013)

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil
por: Iacopetta, B, et al.
Publicado: (2001)

Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta-synthase in oral cancer – a case–control study in southeastern Brazilians()
por: Barbosa, Andressa, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kg84vq7tgdm06479h1m7qi7f4v