Area under the curve of methotrexate and creatinine clearance are outcome-determining factors in primary CNS lymphomas

Although high-dose methotrexate (HD-MTX) is the most effective drug against primary CNS lymphomas (PCNSL), outcome-determining variables related to its administration schedule have not been defined. The impact on toxicity and outcome of the area under the curve (AUC(MTX)), dose intensity (DI(MTX)) a...

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Detalles Bibliográficos
Autores principales: Ferreri, A J M, Guerra, E, Regazzi, M, Pasini, F, Ambrosetti, A, Pivnik, A, Gubkin, A, Calderoni, A, Spina, M, Brandes, A, Ferrarese, F, Rognone, A, Govi, S, Dell'Oro, S, Locatelli, M, Villa, E, Reni, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409565/
https://www.ncbi.nlm.nih.gov/pubmed/14735176
http://dx.doi.org/10.1038/sj.bjc.6601472

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