The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype

Serum and tissue levels of interleukin-6 (IL-6) have been implicated in the biological phenotype of breast carcinoma. A common G/C polymorphism at position −174 of the IL-6 promoter can influence the expression level of this gene. We therefore investigated for associations between this polymorphism...

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Detalles Bibliográficos
Autores principales: Iacopetta, B, Grieu, F, Joseph, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409577/
https://www.ncbi.nlm.nih.gov/pubmed/14735187
http://dx.doi.org/10.1038/sj.bjc.6601545
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author Iacopetta, B
Grieu, F
Joseph, D
author_facet Iacopetta, B
Grieu, F
Joseph, D
author_sort Iacopetta, B
collection PubMed
description Serum and tissue levels of interleukin-6 (IL-6) have been implicated in the biological phenotype of breast carcinoma. A common G/C polymorphism at position −174 of the IL-6 promoter can influence the expression level of this gene. We therefore investigated for associations between this polymorphism and various phenotypic features in a series of 256 breast cancers. Individuals who were homozygous for the C allele (n=55) were more likely to have higher-grade tumours (P=0.039) with ductal histology (P=0.030) compared to those harbouring at least one wild-type G allele (n=201). Homozygosity for the C allele was also associated with significantly worse overall survival (P=0.031). We conclude that the −174 C allele of IL-6 is associated with a more aggressive breast cancer phenotype.
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spelling pubmed-24095772009-09-10 The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype Iacopetta, B Grieu, F Joseph, D Br J Cancer Molecular and Cellular Pathology Serum and tissue levels of interleukin-6 (IL-6) have been implicated in the biological phenotype of breast carcinoma. A common G/C polymorphism at position −174 of the IL-6 promoter can influence the expression level of this gene. We therefore investigated for associations between this polymorphism and various phenotypic features in a series of 256 breast cancers. Individuals who were homozygous for the C allele (n=55) were more likely to have higher-grade tumours (P=0.039) with ductal histology (P=0.030) compared to those harbouring at least one wild-type G allele (n=201). Homozygosity for the C allele was also associated with significantly worse overall survival (P=0.031). We conclude that the −174 C allele of IL-6 is associated with a more aggressive breast cancer phenotype. Nature Publishing Group 2004-01-26 2004-01-20 /pmc/articles/PMC2409577/ /pubmed/14735187 http://dx.doi.org/10.1038/sj.bjc.6601545 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Iacopetta, B
Grieu, F
Joseph, D
The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype
title The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype
title_full The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype
title_fullStr The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype
title_full_unstemmed The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype
title_short The −174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype
title_sort −174 g/c gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409577/
https://www.ncbi.nlm.nih.gov/pubmed/14735187
http://dx.doi.org/10.1038/sj.bjc.6601545
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