Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas

Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/−), Smad4(+/−) and Cdx2(+/−)mice. These results suggest that PGE(2) pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Takeda, H, Miyoshi, H, Tamai, Y, Oshima, M, Taketo, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409590/
https://www.ncbi.nlm.nih.gov/pubmed/14760387
http://dx.doi.org/10.1038/sj.bjc.6601584
Descripción
Sumario:Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/−), Smad4(+/−) and Cdx2(+/−)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.

Ejemplares similares