Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas

Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/−), Smad4(+/−) and Cdx2(+/−)mice. These results suggest that PGE(2) pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Takeda, H, Miyoshi, H, Tamai, Y, Oshima, M, Taketo, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409590/
https://www.ncbi.nlm.nih.gov/pubmed/14760387
http://dx.doi.org/10.1038/sj.bjc.6601584
_version_ 1782155805594746880
author Takeda, H
Miyoshi, H
Tamai, Y
Oshima, M
Taketo, M M
author_facet Takeda, H
Miyoshi, H
Tamai, Y
Oshima, M
Taketo, M M
author_sort Takeda, H
collection PubMed
description Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/−), Smad4(+/−) and Cdx2(+/−)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.
format Text
id pubmed-2409590
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-24095902009-09-10 Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas Takeda, H Miyoshi, H Tamai, Y Oshima, M Taketo, M M Br J Cancer Experimental Therapeutics Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/−), Smad4(+/−) and Cdx2(+/−)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas. Nature Publishing Group 2004-02-09 2004-02-03 /pmc/articles/PMC2409590/ /pubmed/14760387 http://dx.doi.org/10.1038/sj.bjc.6601584 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Takeda, H
Miyoshi, H
Tamai, Y
Oshima, M
Taketo, M M
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
title Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
title_full Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
title_fullStr Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
title_full_unstemmed Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
title_short Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
title_sort simultaneous expression of cox-2 and mpges-1 in mouse gastrointestinal hamartomas
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409590/
https://www.ncbi.nlm.nih.gov/pubmed/14760387
http://dx.doi.org/10.1038/sj.bjc.6601584
work_keys_str_mv AT takedah simultaneousexpressionofcox2andmpges1inmousegastrointestinalhamartomas
AT miyoshih simultaneousexpressionofcox2andmpges1inmousegastrointestinalhamartomas
AT tamaiy simultaneousexpressionofcox2andmpges1inmousegastrointestinalhamartomas
AT oshimam simultaneousexpressionofcox2andmpges1inmousegastrointestinalhamartomas
AT taketomm simultaneousexpressionofcox2andmpges1inmousegastrointestinalhamartomas

Ejemplares similares