Cargando…

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFβ2

MUC4 is highly expressed in human pancreatic tumours and pancreatic tumour cell lines, but is minimally or not expressed in normal pancreas or chronic pancreatitis. Here, we investigated the aberrant regulation of MUC4 expression in vivo using clonal human pancreatic tumour cells (CD18/HPAF) grown e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choudhury, A, Moniaux, N, Ulrich, A B, Schmied, B M, Standop, J, Pour, P M, Gendler, S J, Hollingsworth, M A, Aubert, J-P, Batra, S K
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409611/ https://www.ncbi.nlm.nih.gov/pubmed/14760381 http://dx.doi.org/10.1038/sj.bjc.6601604

Ejemplares similares

MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
por: Matull, W R, et al.
Publicado: (2008)

Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
por: Lewis, M P, et al.
Publicado: (2004)

Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
por: Moniaux, N, et al.
Publicado: (2008)

Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells
por: Moniaux, N, et al.
Publicado: (2007)

MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells
por: Ponnusamy, M P, et al.
Publicado: (2008)

Allelic loss at 19q12 and Xq11–12 predict an adverse clinical outcome in patients with mucinous ovarian tumours of low malignant potential
por: Nakayama, K, et al.
Publicado: (2004)

Heterogeneity of O(6)-alkylguanine DNA-alkyltransferase expression in human breast tumours
por: Clemons, M J, et al.
Publicado: (2002)

Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients
por: Weigelt, B, et al.
Publicado: (2003)

The embedded tumour: host physiology is important for the evaluation of tumour growth
por: van Leeuwen, I M M, et al.
Publicado: (2003)

p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer
por: Fondevila, C, et al.
Publicado: (2004)

Prognostic impact of chromosomal aberrations in Ewing tumours
por: Hattinger, C M, et al.
Publicado: (2002)

A model for co-expression pattern analysis of genes implicated in angiogenesis and tumour cell invasion in cervical cancer
por: Van Trappen, P O, et al.
Publicado: (2002)

Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development
por: Zuidervaart, W, et al.
Publicado: (2003)

High level amplification of N-MYC is not associated with adverse histology or outcome in primary retinoblastoma tumours
por: Lillington, D M, et al.
Publicado: (2002)

CpG island methylation status and mutation analysis of the RB1 gene essential promoter region and protein-binding pocket domain in nervous system tumours
por: Gonzalez-Gomez, P, et al.
Publicado: (2003)

Increased aquaporin 1 water channel expression inhuman brain tumours
por: Saadoun, S, et al.
Publicado: (2002)

Flow cytometric quantification of tumour endothelial cells; an objective alternative for microvessel density assessment
por: Baeten, C I M, et al.
Publicado: (2002)

The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system
por: Burns, A S Y W, et al.
Publicado: (2002)

Binding of TGF-β1 latency-associated peptide (LAP) to αvβ6 integrin modulates behaviour of squamous carcinoma cells
por: Thomas, G J, et al.
Publicado: (2002)

Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function
por: Bhat-Nakshatri, P, et al.
Publicado: (2004)

Intra-tumoural microvessel density in human solid tumours
por: Hasan, J, et al.
Publicado: (2002)

Comparison of the RNA-amplification based methods RT–PCR and NASBA for the detection of circulating tumour cells
por: Burchill, S A, et al.
Publicado: (2002)

RARRES3 expression positively correlated to tumour differentiation in tissues of colorectal adenocarcinoma
por: Shyu, R-Y, et al.
Publicado: (2003)

On the biological relevance of MHC class II and B7 expression by tumour cells in melanoma metastases
por: Bernsen, M R, et al.
Publicado: (2003)

Discrimination between uterine serous papillary carcinomas and ovarian serous papillary tumours by gene expression profiling
por: Santin, A D, et al.
Publicado: (2004)

Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis
por: Yousef, G M, et al.
Publicado: (2002)

Wnt-signalling pathway in ovarian epithelial tumours: increased expression of β-catenin and GSK3β
por: Rask, K, et al.
Publicado: (2003)

Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
por: Tynninen, O, et al.
Publicado: (2002)

Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours
por: Zurita, A J, et al.
Publicado: (2003)

Sensitive detection of tumour cells in effusions by combining cytology and fluorescence in situ hybridisation (FISH)
por: Fiegl, M, et al.
Publicado: (2004)

The coxsackievirus and adenovirus receptor acts as a tumour suppressor in malignant glioma cells
por: Kim, M, et al.
Publicado: (2003)

DNA topoisomerase I and II expression in drug resistantgerm cell tumours
por: Berney, D M, et al.
Publicado: (2002)

Accumulation of uPA – PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone-receptor-positive early breast cancer
por: Schneider, J, et al.
Publicado: (2003)

Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status
por: Perel, Y, et al.
Publicado: (2002)

Effect of neoadjuvant treatment with anastrozole on tumour histology in postmenopausal women with large operable breast cancer
por: Anderson, T J, et al.
Publicado: (2002)

Tumour stage, node stage, p53 gene status, and bcl-2 protein expression as predictors of tumour response to platin-fluorouracil chemotherapy in patients with squamous-cell carcinoma of the head and neck
por: Fouret, P, et al.
Publicado: (2002)

Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer
por: Dirix, L Y, et al.
Publicado: (2002)

Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours
por: Lantuejoul, S, et al.
Publicado: (2004)

Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage
por: Pardo, F S, et al.
Publicado: (2004)

Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin
por: Bafna, S, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_f8lfmr16s46di7novamht5vlo5