Cargando…
Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
Gene expression analysis was performed on a human renal cancer cell line (786-0) with mutated VHL gene and a transfectant with wild-type VHL to analyse genes regulated by VHL and to compare with the gene programme regulated by hypoxia. There was a highly significant concordance of the global gene re...
Autores principales: | Wykoff, C C, Sotiriou, C, Cockman, M E, Ratcliffe, P J, Maxwell, P, Liu, E, Harris, A L |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2004
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409644/ https://www.ncbi.nlm.nih.gov/pubmed/15026807 http://dx.doi.org/10.1038/sj.bjc.6601657 |
Ejemplares similares
-
Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
por: Gemmill, R M, et al.
Publicado: (2005) -
VHL and Hypoxia Signaling: Beyond HIF in Cancer
por: Zhang, Jing, et al.
Publicado: (2018) -
VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
por: Artemov, Artem V., et al.
Publicado: (2018) -
Frequent Mutations of VHL Gene and the Clinical Phenotypes in the Largest Chinese Cohort With Von Hippel–Lindau Disease
por: Hong, Baoan, et al.
Publicado: (2019) -
Novel and recurrent genetic variants of VHL, SDHB, and RET genes in Chinese pheochromocytoma and paraganglioma patients
por: Li, Chong, et al.
Publicado: (2023)