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A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin

Mdm2 is frequently overexpressed in sarcoma cells and may contribute to drug resistance by increasing p53 degradation. We investigated the induction of apoptosis in sarcoma cells via adenovirus-mediated gene transfer of wild-type p53 and two modified p53 genes, p53 14/19 and p53 22/23, whose protein...

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Detalles Bibliográficos
Autores principales:	Tang, H-J, Qian, D, Sondak, V K, Stachura, S, Lin, J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409661/ https://www.ncbi.nlm.nih.gov/pubmed/15026814 http://dx.doi.org/10.1038/sj.bjc.6601653

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