The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer

At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin...

Descripción completa

Detalles Bibliográficos
Autores principales: Barber, M D, McMillan, D C, Wallace, A M, Ross, J A, Preston, T, Fearon, K C H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409662/
https://www.ncbi.nlm.nih.gov/pubmed/15026790
http://dx.doi.org/10.1038/sj.bjc.6601712
_version_ 1782155826334531584
author Barber, M D
McMillan, D C
Wallace, A M
Ross, J A
Preston, T
Fearon, K C H
author_facet Barber, M D
McMillan, D C
Wallace, A M
Ross, J A
Preston, T
Fearon, K C H
author_sort Barber, M D
collection PubMed
description At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05), but less for leptin in the cancer group (P<0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer.
format Text
id pubmed-2409662
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-24096622009-09-10 The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer Barber, M D McMillan, D C Wallace, A M Ross, J A Preston, T Fearon, K C H Br J Cancer Clinical At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05), but less for leptin in the cancer group (P<0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer. Nature Publishing Group 2004-03-22 2004-03-02 /pmc/articles/PMC2409662/ /pubmed/15026790 http://dx.doi.org/10.1038/sj.bjc.6601712 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Barber, M D
McMillan, D C
Wallace, A M
Ross, J A
Preston, T
Fearon, K C H
The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
title The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
title_full The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
title_fullStr The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
title_full_unstemmed The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
title_short The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
title_sort response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409662/
https://www.ncbi.nlm.nih.gov/pubmed/15026790
http://dx.doi.org/10.1038/sj.bjc.6601712
work_keys_str_mv AT barbermd theresponseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT mcmillandc theresponseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT wallaceam theresponseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT rossja theresponseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT prestont theresponseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT fearonkch theresponseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT barbermd responseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT mcmillandc responseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT wallaceam responseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT rossja responseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT prestont responseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer
AT fearonkch responseofleptininterleukin6andfatoxidationtofeedinginweightlosingpatientswithpancreaticcancer

Ejemplares similares