Breast cancer prognosis in relation to family history of breast and ovarian cancer

We linked four nationwide Swedish population-based registries to identify first-degree family history of breast and ovarian cancer among breast cancer cases diagnosed between 1991 and 1998 and followed them until death, emigration or end of follow-up in December 1998. The median follow-up was 36 mon...

Descripción completa

Detalles Bibliográficos
Autores principales: Thalib, L, Wedrén, S, Granath, F, Adami, H-O, Rydh, B, Magnusson, C, Hall, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409691/
https://www.ncbi.nlm.nih.gov/pubmed/15054458
http://dx.doi.org/10.1038/sj.bjc.6601694
_version_ 1782155834735722496
author Thalib, L
Wedrén, S
Granath, F
Adami, H-O
Rydh, B
Magnusson, C
Hall, P
author_facet Thalib, L
Wedrén, S
Granath, F
Adami, H-O
Rydh, B
Magnusson, C
Hall, P
author_sort Thalib, L
collection PubMed
description We linked four nationwide Swedish population-based registries to identify first-degree family history of breast and ovarian cancer among breast cancer cases diagnosed between 1991 and 1998 and followed them until death, emigration or end of follow-up in December 1998. The median follow-up was 36 months. Using Cox proportional hazards models, the hazard ratio of death (HR) due to breast cancer was estimated. Women with a family history of breast or ovarian cancer (n=2175, 12.7%) had a nonsignificantly better prognosis than women without any family history, HR 0.86 (95% CI 0.71–1.05); this appeared unrelated to age at diagnosis either in the index case or in relative(s) with breast and/or ovarian cancer. Our study shows that prognostic outlook is not worse among breast cancer patients with family history.
format Text
id pubmed-2409691
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-24096912009-09-10 Breast cancer prognosis in relation to family history of breast and ovarian cancer Thalib, L Wedrén, S Granath, F Adami, H-O Rydh, B Magnusson, C Hall, P Br J Cancer Epidemiology We linked four nationwide Swedish population-based registries to identify first-degree family history of breast and ovarian cancer among breast cancer cases diagnosed between 1991 and 1998 and followed them until death, emigration or end of follow-up in December 1998. The median follow-up was 36 months. Using Cox proportional hazards models, the hazard ratio of death (HR) due to breast cancer was estimated. Women with a family history of breast or ovarian cancer (n=2175, 12.7%) had a nonsignificantly better prognosis than women without any family history, HR 0.86 (95% CI 0.71–1.05); this appeared unrelated to age at diagnosis either in the index case or in relative(s) with breast and/or ovarian cancer. Our study shows that prognostic outlook is not worse among breast cancer patients with family history. Nature Publishing Group 2004-04-05 2004-02-24 /pmc/articles/PMC2409691/ /pubmed/15054458 http://dx.doi.org/10.1038/sj.bjc.6601694 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Thalib, L
Wedrén, S
Granath, F
Adami, H-O
Rydh, B
Magnusson, C
Hall, P
Breast cancer prognosis in relation to family history of breast and ovarian cancer
title Breast cancer prognosis in relation to family history of breast and ovarian cancer
title_full Breast cancer prognosis in relation to family history of breast and ovarian cancer
title_fullStr Breast cancer prognosis in relation to family history of breast and ovarian cancer
title_full_unstemmed Breast cancer prognosis in relation to family history of breast and ovarian cancer
title_short Breast cancer prognosis in relation to family history of breast and ovarian cancer
title_sort breast cancer prognosis in relation to family history of breast and ovarian cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409691/
https://www.ncbi.nlm.nih.gov/pubmed/15054458
http://dx.doi.org/10.1038/sj.bjc.6601694
work_keys_str_mv AT thalibl breastcancerprognosisinrelationtofamilyhistoryofbreastandovariancancer
AT wedrens breastcancerprognosisinrelationtofamilyhistoryofbreastandovariancancer
AT granathf breastcancerprognosisinrelationtofamilyhistoryofbreastandovariancancer
AT adamiho breastcancerprognosisinrelationtofamilyhistoryofbreastandovariancancer
AT rydhb breastcancerprognosisinrelationtofamilyhistoryofbreastandovariancancer
AT magnussonc breastcancerprognosisinrelationtofamilyhistoryofbreastandovariancancer
AT hallp breastcancerprognosisinrelationtofamilyhistoryofbreastandovariancancer

Ejemplares similares