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Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells
Most small cell lung cancers (SCLC) coexpress the c-kit protein tyrosine receptor kinase and its ligand stem cell factor, resulting in an autocrine loop. As SCLC growth is also driven by insulin-like growth factor-1 receptor (IGF-1R) signalling, tyrphostins AG 1024 and 1296 (inhibitors of IGF-1R and...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409731/ https://www.ncbi.nlm.nih.gov/pubmed/15150607 http://dx.doi.org/10.1038/sj.bjc.6601682 |