Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats

Here we show that Doxil® has minimal antitumour activity in the isolated limb perfusion (ILP) setting and its activity was not enhanced by the addition of tumour necrosis factor (TNF). Doxil® accumulation in tumour tissue was low and also not augmented by TNF. In contrast, activity of free conventio...

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Autores principales: ten Hagen, T L M, Hoving, S, Ambagtsheer, G, van Tiel, S T, Eggermont, A M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409755/
https://www.ncbi.nlm.nih.gov/pubmed/15208623
http://dx.doi.org/10.1038/sj.bjc.6601688
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author ten Hagen, T L M
Hoving, S
Ambagtsheer, G
van Tiel, S T
Eggermont, A M M
author_facet ten Hagen, T L M
Hoving, S
Ambagtsheer, G
van Tiel, S T
Eggermont, A M M
author_sort ten Hagen, T L M
collection PubMed
description Here we show that Doxil® has minimal antitumour activity in the isolated limb perfusion (ILP) setting and its activity was not enhanced by the addition of tumour necrosis factor (TNF). Doxil® accumulation in tumour tissue was low and also not augmented by TNF. In contrast, activity of free conventional doxorubicin was enhanced by TNF. We conclude that application of Doxil® in a TNF-based ILP is not a useful alternative to free conventional doxorubicin or melphalan.
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spelling pubmed-24097552009-09-10 Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats ten Hagen, T L M Hoving, S Ambagtsheer, G van Tiel, S T Eggermont, A M M Br J Cancer Experimental Therapeutics Here we show that Doxil® has minimal antitumour activity in the isolated limb perfusion (ILP) setting and its activity was not enhanced by the addition of tumour necrosis factor (TNF). Doxil® accumulation in tumour tissue was low and also not augmented by TNF. In contrast, activity of free conventional doxorubicin was enhanced by TNF. We conclude that application of Doxil® in a TNF-based ILP is not a useful alternative to free conventional doxorubicin or melphalan. Nature Publishing Group 2004-05-04 2004-04-27 /pmc/articles/PMC2409755/ /pubmed/15208623 http://dx.doi.org/10.1038/sj.bjc.6601688 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
ten Hagen, T L M
Hoving, S
Ambagtsheer, G
van Tiel, S T
Eggermont, A M M
Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
title Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
title_full Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
title_fullStr Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
title_full_unstemmed Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
title_short Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats
title_sort lack of efficacy of doxil® in tnf-α-based isolated limb perfusion in sarcoma-bearing rats
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409755/
https://www.ncbi.nlm.nih.gov/pubmed/15208623
http://dx.doi.org/10.1038/sj.bjc.6601688
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AT ambagtsheerg lackofefficacyofdoxilintnfabasedisolatedlimbperfusioninsarcomabearingrats
AT vantielst lackofefficacyofdoxilintnfabasedisolatedlimbperfusioninsarcomabearingrats
AT eggermontamm lackofefficacyofdoxilintnfabasedisolatedlimbperfusioninsarcomabearingrats

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