The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions

The presence of high-risk human papillomavirus, loss of heterozygosity on chromosome 3p and fragile histidine triad gene expression were assessed as potential markers of cancer and CIN progression in 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions. Human papillomavirus...

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Autores principales: Terry, G, Ho, L, Londesborough, P, Cross, P, Lopes, A, Monaghan, J, Cuzick, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409782/
https://www.ncbi.nlm.nih.gov/pubmed/15570308
http://dx.doi.org/10.1038/sj.bjc.6602253
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author Terry, G
Ho, L
Londesborough, P
Cross, P
Lopes, A
Monaghan, J
Cuzick, J
author_facet Terry, G
Ho, L
Londesborough, P
Cross, P
Lopes, A
Monaghan, J
Cuzick, J
author_sort Terry, G
collection PubMed
description The presence of high-risk human papillomavirus, loss of heterozygosity on chromosome 3p and fragile histidine triad gene expression were assessed as potential markers of cancer and CIN progression in 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions. Human papillomavirus type 16 was an indicator of vascular involvement in cancers. Loss of heterozygosity, especially in the fragile histidine triad gene intron 5, was an indicator of high-grade tumours, greater tumour depth and lymph node involvement. Abnormal fragile histidine triad gene expression was more frequent in cervical intraepithelial neoplasia grade 1 lesions with increased risk of disease progression.
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spelling pubmed-24097822009-09-10 The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions Terry, G Ho, L Londesborough, P Cross, P Lopes, A Monaghan, J Cuzick, J Br J Cancer Molecular and Cellular Pathology The presence of high-risk human papillomavirus, loss of heterozygosity on chromosome 3p and fragile histidine triad gene expression were assessed as potential markers of cancer and CIN progression in 83 cervical cancers and 74 cervical intraepithelial neoplasia grade 1 lesions. Human papillomavirus type 16 was an indicator of vascular involvement in cancers. Loss of heterozygosity, especially in the fragile histidine triad gene intron 5, was an indicator of high-grade tumours, greater tumour depth and lymph node involvement. Abnormal fragile histidine triad gene expression was more frequent in cervical intraepithelial neoplasia grade 1 lesions with increased risk of disease progression. Nature Publishing Group 2004-12-13 2004-11-30 /pmc/articles/PMC2409782/ /pubmed/15570308 http://dx.doi.org/10.1038/sj.bjc.6602253 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Terry, G
Ho, L
Londesborough, P
Cross, P
Lopes, A
Monaghan, J
Cuzick, J
The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
title The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
title_full The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
title_fullStr The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
title_full_unstemmed The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
title_short The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
title_sort role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409782/
https://www.ncbi.nlm.nih.gov/pubmed/15570308
http://dx.doi.org/10.1038/sj.bjc.6602253
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