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Monitoring HSVtk suicide gene therapy: the role of [(18)F]FHPG membrane transport

Favourable pharmacokinetics of the prodrug are essential for successful HSVtk/ganciclovir (GCV) suicide gene therapy. [(18)F]FHPG PET might be a suitable technique to assess the pharmacokinetics of the prodrug GCV noninvasively, provided that [(18)F]FHPG mimics the behaviour of GCV. Since membrane t...

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Detalles Bibliográficos
Autores principales:	Buursma, A R, van Dillen, I J, van Waarde, A, Vaalburg, W, Hospers, G A P, Mulder, N H, de Vries, E F J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409793/ https://www.ncbi.nlm.nih.gov/pubmed/15599382 http://dx.doi.org/10.1038/sj.bjc.6602216

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